Design, Synthesis, and In Vitro Antimicrobial Evaluation of Fused Pyrano[3,2-e]tetrazolo[1,5-c]pyrimidines and Diazepines

Table 1

Minimum inhibitory concentration (MIC, 𝜇g/mL) of the synthesized compounds 2a–f, 3a–f, 4a–f, and 5a–f.

Compound	Gram-positive bacteria		Gram-negative bacteria		Fungi
	B. subtilis	S. aureus	P. aeuroginosa	E. coli	C. albicans	A. niger
2a	400	400	—	—	400	400
2b	400	200	200	400	200	50
2c	400	400	400	200	50	400
2d	400	400	200	400	400	200
2e	200	400	400	200	200	400
2f	—	—	—	—	—	—
3a	400	400	200	200	400	200
3b	25	100	100	50	100	50
3c	200	400	200	400	200	200
3d	400	200	200	400	200	400
3e	25	100	100	25	50	100
3f	400	400	400	400	400	400
4a	400	400	400	400	200	400
4b	100	50	200	100	50	200
4c	400	200	400	400	400	400
4d	200	400	400	200	400	200
4e	200	100	50	100	200	50
4f	400	200	400	400	400	200
5a	—	—	—	—	—	—
5b	200	400	—	400	—	200
5c	—	400	400	—	400	400
5d	400	200	200	—	200	—
5e	200	400	200	400	200	400
5f	—	—	—	—	—	—
Ciprofloxacin	6.25	6.25	6.25	6.25
Fluconazole					6.25	6.25