Table of Contents
ISRN Cardiology
Volume 2013 (2013), Article ID 635439, 5 pages
http://dx.doi.org/10.1155/2013/635439
Research Article

Risk Factors for Asymptomatic Ventricular Dysfunction in Rheumatoid Arthritis Patients

1Internal Medicine Department, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, 03100 Mexico City, DF, Mexico
2Heart Failure Clinic, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, 03100 Mexico City, DF, Mexico
3Cardiology Department, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, 03100 Mexico City, DF, Mexico
4Massachusetts General Hospital Interpreter Services, Boston, MA 02114, USA

Received 17 July 2013; Accepted 8 October 2013

Academic Editors: A. Becker, A. Bobik, C. Gonzalez-Juanatey, and A. Szekely

Copyright © 2013 Carlos Garza-García et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of the study was to describe echocardiographic abnormalities in patients with rheumatoid arthritis, concurrent systemic comorbidities, rheumatologic clinical activity, serologic markers of rheumatoid arthritis, and inflammatory activity. Methods. In an observational, cross-sectional study, rheumatoid arthritis outpatients were included ( ). Conventional transthoracic echocardiographic variables were compared between patients with arthritis and non-RA controls ( ). For rheumatoid arthritis patients, articular activity and rheumatologic and inflammatory markers were obtained. Results. Ventricular dysfunction was found in 54.3% of the population: systolic (18.1%), diastolic (32.4%), and/or right (24.8%), with lower ejection fraction ( ). Pulmonary hypertension was found in 46.9%. Other echocardiographic findings included increased left atrial diameter ( ), aortic diameter ( ), ventricular septum ( ), left ventricular posterior wall ( ), and right ventricular ( ) and atrial diameters compared to control subjects. Rheumatoid factor and anti-CCP antibodies levels were significantly elevated in cases with ventricular dysfunction. Angina and myocardial infarction, diabetes, and dyslipidemia were the main risk factors for ventricular dysfunction. Conclusions. Ventricular dysfunction is common in rheumatoid arthritis and associated with longer disease duration and increased serologic markers of rheumatoid arthritis. Screening for cardiac abnormalities should be considered in this kind of patients.