Table of Contents
ISRN Nephrology
Volume 2013 (2013), Article ID 636208, 4 pages
http://dx.doi.org/10.5402/2013/636208
Clinical Study

Effect of N-Acetylcysteine on Residual Renal Function in Chronic Haemodialysis Patients Treated with High-Flux Synthetic Dialysis Membranes: A Pilot Study

1Nephrology Division and Research & Development Unit, Assaf Harofeh Medical Center, Zerifin 70300, Israel
2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
3Family Medicine Department, Clalit Health Services and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 97904, Israel

Received 3 October 2012; Accepted 23 October 2012

Academic Editors: C. Musso and S. Opatrná

Copyright © 2013 Leonid Feldman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Bargman, K. E. Thorpe, and D. N. Churchill, “Relative contribution of residual renal function and peritoneal clearance to adequacy of dialysis: a reanalysis of the CANUSA study,” Journal of the American Society of Nephrology, vol. 12, no. 10, pp. 2158–2162, 2001. View at Google Scholar · View at Scopus
  2. Z. Z. Brener, S. Thijssen, P. Kotanko et al., “The impact of residual renal function on hospitalization and mortality in incident hemodialysis patients,” Blood Purification, vol. 31, no. 4, pp. 243–251, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Shemin, A. G. Bostom, P. Laliberty, and L. D. Dworkin, “Residual renal function and mortality risk in hemodialysis patients,” American Journal of Kidney Diseases, vol. 38, no. 1, pp. 85–90, 2001. View at Google Scholar · View at Scopus
  4. F. Termorshuizen, F. W. Dekker, J. G. Van Manen, J. C. Korevaar, E. W. Boeschoten, and R. T. Krediet, “Relative contribution of residual renal function and different measures of adequacy to survival in hemodialysis patients: an analysis of the Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD)-2,” Journal of the American Society of Nephrology, vol. 15, no. 4, pp. 1061–1070, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. M. van de Luijtgaarden, M. Noordzij, C. Wanner, and K. Jager, “Renal replacement therapy in Europe—a summary of the 2009 ERA-EDTA annual Report,” Clinical Kidney Journal, vol. 5, pp. 109–119, 2012. View at Google Scholar
  6. L. M. Moist, F. K. Port, S. M. Orzol et al., “Predictors of loss of residual renal function among new dialysis patients,” Journal of the American Society of Nephrology, vol. 11, no. 3, pp. 556–564, 2000. View at Google Scholar · View at Scopus
  7. W. McKane, S. M. Chandna, J. E. Tattersall, R. N. Greenwood, and K. Farrington, “Identical decline of residual renal function in high-flux biocompatible hemodialysis and CAPD,” Kidney International, vol. 61, no. 1, pp. 256–265, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Feldman, M. Shani, I. Sinuani, I. Beberashvili, and J. Weissgarten, “N-acetylcysteine may improve residual renal function in hemodialysis patients: a pilot study,” Hemodialysis International, vol. 16, no. 4, pp. 512–516, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Feldman, M. Shani, S. Efrati et al., “N-acetylcysteine improves residual renal function in peritoneal dialysis patients: a pilot study,” Peritoneal Dialysis International, vol. 31, no. 5, pp. 545–550, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. National Kidney Foundation, “K/DOQI Clinical Practice Guidelines for Hemodialysis Adequacy: update 2006,” American Journal of Kidney Diseases, vol. 48, supplement 1, pp. S17–S23, 2006. View at Google Scholar
  11. D. Fouque, M. Vennegoor, P. ter Wee et al., “EBPG guideline on nutrition,” Nephrology, Dialysis, Transplantation, vol. 22, supplement 2, pp. ii45–ii87, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Tepel, M. Van der Giet, M. Statz, J. Jankowski, and W. Zidek, “The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: a randomized, controlled trial,” Circulation, vol. 107, no. 7, pp. 992–995, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. S. N. Heyman, M. Goldfarb, A. Shina, F. Karmeli, and S. Rosen, “N-acetylcysteine ameliorates renal microcirculation: studies in rats,” Kidney International, vol. 63, no. 2, pp. 634–641, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Mittermayer, G. Schaller, J. Pleiner et al., “Asymmetrical dimethylarginine plasma concentrations are related to basal nitric oxide release but not endothelium-dependent vasodilation of resistance arteries in peritoneal dialysis patients,” Journal of the American Society of Nephrology, vol. 16, no. 6, pp. 1832–1838, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Thaha, Widodo, W. Pranawa, M. Yogiantoro, and Y. Tomino, “Intravenous N-acetylcysteine during hemodialysis reduces asymmetric dimethylarginine level in end-stage renal disease patients,” Clinical Nephrology, vol. 69, no. 1, pp. 24–32, 2008. View at Google Scholar · View at Scopus