n5-STZ Diabetic Model Develops Alterations in Sciatic Nerve and Dorsal Root Ganglia Neurons of Wistar Rats

Table 1

Passive and active electrical properties of intact dorsal root ganglia neurons from control, near-normoglycemic, and hyperglycemic, groups. Data are illustrated as mean ± S.E.M (𝑛), where the value in parenthesis indicates the number of neurons.

Parameter	Control	Near-normoglycemic	Hyperglycemic
Resting potential (mV)	−58.3 ± 1.7 (11)	−60.2 ± 1.0 (16)	−54.0 ± 1.4^a (11)
Input resistance (MΩ)	14.9 ± 2.2 (10)	13.8 ± 2.1 (16)	12.3 ± 1.5 (10)
Limiar current (pA)	1909.1 ± 315.2 (11)	1668.8 ± 147.1 (16)	1618.2 ± 202.2 (11)
AP amplitude (mV)	72.7 ± 3.6 (11)	73.5 ± 3.2 (16)	66.1 ± 3.9 (11)
AP duration (ms)	0.9 ± 0.1 (11)	0.9 ± 0.1 (16)	2.0 ± 0.3^a (11)
Maximum ascendant inclination (V/s)	195.5 ± 28.9 (11)	191.2 ± 19.1 (16)	110.9 ± 15.3^a (11)
Maximum descendant inclination (V/s)	124.5 ± 15.0 (11)	115.6 ± 10.8 (16)	75.5 ± 9.2^a (11)

AP: action potential; ^aindicates statistical difference compared to control group (𝑃<0.05, ANOVA followed by Student-Newman-Keuls comparisons test for resting potential and maximum ascendant inclination and 𝑃<0.05, ANOVA on ranks followed by Dunn’s comparisons test for AP duration and maximum descendant inclination).