Table of Contents
ISRN Biomaterials
Volume 2013, Article ID 640895, 4 pages
Research Article

Characterization of an In Vitro Model of Extracorporeal Circulation: A New Tool for Investigating the Pathophysiological and Therapeutic Strategies in Whole Blood

1The Cardiothoracic Centre, Liverpool NHS Trust, Thomas Drive, Liverpool L14 3PE, UK
2Division of Cardiothoracic Surgery, Department of Surgery, Texas A&M Health Science Center at Scott & White Memorial Hospital, 2401 S. 31st Street Temple, TX 76508, USA

Received 16 June 2013; Accepted 8 July 2013

Academic Editors: X. Li and B. Walkowiak

Copyright © 2013 Bashir M. Matata and Maqsood M. Elahi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Asimakopoulos, P. L. C. Smith, C. P. Ratnatunga, and K. M. Taylor, “Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass,” Annals of Thoracic Surgery, vol. 68, no. 3, pp. 1107–1115, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. B. M. Matata, A. W. Sosnowski, and M. Galiñanes, “Off-pump bypass graft operation significantly reduces oxidative stress and inflammation,” Annals of Thoracic Surgery, vol. 69, no. 3, pp. 785–791, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Panas, F. H. Khadour, C. Szabó, and R. Schulz, “Proinflammatory cytokines depress cardiac efficiency by a nitric oxide- dependent mechanism,” American Journal of Physiology, vol. 275, no. 3, pp. H1016–H1023, 1998. View at Google Scholar · View at Scopus
  4. B. M. Matata and M. Galiñanes, “Cardiopulmonary bypass exacerbates oxidative stress but does not increase proinflammatory cytokine release in patients with diabetes compared with patients without diabetes: regulatory effects of exogenous nitric oxide,” Journal of Thoracic and Cardiovascular Surgery, vol. 120, no. 1, pp. 1–11, 2000. View at Google Scholar · View at Scopus
  5. T. Gourlay, P. K. Ballaux, E. R. C. Draper, and K. M. Taylor, “Early experience with a new technique and technology designed for the study of pulsatile cardiopulmonary bypass in the rat,” Perfusion, vol. 17, no. 3, pp. 191–198, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. X. M. You, F. Nasrallah, E. Darling, M. Robins, G. Nieman, and B. Searles, “Rat cardiopulmonary bypass model: application of a miniature extracorporeal circuit composed of asanguinous prime,” Journal of Extra-Corporeal Technology, vol. 37, no. 1, pp. 60–65, 2005. View at Google Scholar · View at Scopus
  7. R. C. Lijana and M. C. Williams, “Tetramethylbenzidine-a substitute for benzidine in hemoglobin analysis,” Journal of Laboratory and Clinical Medicine, vol. 94, no. 2, pp. 266–276, 1979. View at Google Scholar · View at Scopus
  8. M. M. Elahi and B. M. Matata, “Blood-dependent redox activity during extracorporeal circulation in health and disease,” The Cardiology, vol. 1, pp. 156–157, 2005. View at Google Scholar
  9. M. M. Elahi, J. M. Courtney, and B. M. Matata, “The interaction between reactive oxidant species and proinflammatory cytokines in human blood during extracorporeal circulation,” Filtration, vol. 1, pp. 89–94, 2005. View at Google Scholar
  10. M. M. Elahi, M. Elahi, and B. M. Matata, “Reactive oxidant species augment complement function in human blood independently of classical and MBL-pathways,” International Journal of Molecular Medicine and Advance Sciences, vol. 1, pp. 382–391, 2005. View at Google Scholar