Table of Contents
ISRN Nanomaterials
Volume 2013, Article ID 646284, 14 pages
Review Article

Development of Magnetic Nanoparticles for Cancer Gene Therapy: A Comprehensive Review

1Department of Immunology and Oncology & Nanobiomedicine Initiative, National Center for Biotechnology (CNB)/CSIC, Darwin 3, Cantoblanco, 28049 Madrid, Spain
2Department of Biomaterials and Bioinspired Materials, Institute of Materials Science of Madrid (ICMM)/CSIC, Sor Juana Inés de la Cruz 3, Cantoblanco, 28049 Madrid, Spain

Received 10 July 2013; Accepted 13 August 2013

Academic Editors: M. R. Ferreira and N. R. Jana

Copyright © 2013 Vladimir Mulens et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Since they were first proposed as nonviral transfection agents for their gene-carrying capacity, magnetic nanoparticles have been studied thoroughly, both in vitro and in vivo. Great effort has been made to manufacture biocompatible magnetic nanoparticles for use in the theragnosis of cancer and other diseases. Here we survey recent advances in the study of magnetic nanoparticles, as well as the polymers and other coating layers currently available for gene therapy, their synthesis, and bioconjugation processes. In addition, we review several gene therapy models based on magnetic nanoparticles.