Table of Contents
ISRN Dermatology
Volume 2013 (2013), Article ID 651590, 6 pages
http://dx.doi.org/10.1155/2013/651590
Research Article

Toxic Epidermal Necrolysis and Graft-versus-Host Reaction: Revisiting a Puzzling Similarity

1Laboratory of Skin Bioengineering and Imaging (LABIC), Department of Clinical Sciences, University of Liège, 4000 Liège, Belgium
2University of Franche-Comté, 25030 Besançon, France
3Department of Dermatopathology, Unilab Lg, Liège University Hospital, 4000 Liège, Belgium
4Intensive Care Department and Burn Centre, Liège University Hospital, 4000 Liège, Belgium

Received 4 April 2013; Accepted 12 May 2013

Academic Editors: E. Alpsoy and B. Amichai

Copyright © 2013 G. E. Piérard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. E. Piérard and P. Paquet, “Facing up to toxic epidermal necrolysis,” Expert Opinion on Pharmacotherapy, vol. 11, no. 15, pp. 2443–2446, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. P. O. Fritsch and A. Sidoroff, “Drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis,” American Journal of Clinical Dermatology, vol. 1, no. 6, pp. 349–360, 2000. View at Google Scholar · View at Scopus
  3. R. Abe, T. Shimizu, A. Shibaki, H. Nakamura, H. Watanabe, and H. Shimizu, “Toxic epidermal necrolysis and Stevens-Johnson syndrome are induced by soluble fas ligand,” American Journal of Pathology, vol. 162, no. 5, pp. 1515–1520, 2003. View at Google Scholar · View at Scopus
  4. B. Khalili and S. L. Bahna, “Pathogenesis and recent therapeutic trends in Stevens-Johnson syndrome and toxic epidermal necrolysis,” Annals of Allergy, Asthma and Immunology, vol. 97, no. 3, pp. 272–281, 2006. View at Google Scholar · View at Scopus
  5. A. T. Borchers, J. L. Lee, S. M. Naguwa, G. S. Cheema, and M. E. Gershwin, “Stevens-Johnson syndrome and toxic epidermal necrolysis,” Autoimmunity Reviews, vol. 7, no. 8, pp. 598–605, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Mockenhaupt, “The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis,” Expert Review of Clinical Immunology, vol. 7, no. 6, pp. 803–813, 2011. View at Google Scholar
  7. R. Forman, G. Koren, and N. H. Shear, “Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a review of 10 years' experience,” Drug Safety, vol. 25, no. 13, pp. 965–972, 2002. View at Google Scholar · View at Scopus
  8. R. Watanabe, H. Watanabe, C. Sotozono et al., “Critical factors differentiating erythema multiforme majus from Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN),” European Journal of Dermatology, vol. 21, no. 6, pp. 889–894, 2011. View at Google Scholar
  9. S. Iwai, H. Sueki, H. Watanabe et al., “Distinguishing between erythema multiforme major and Stevens-Johnson syndrome/toxic epidermal necrolysis immunopathologically,” Journal of Dermatology, vol. 39, no. 9, pp. 781–786, 2012. View at Google Scholar
  10. F. A. Pereira, A. V. Mudgil, and D. M. Rosmarin, “Toxic epidermal necrolysis,” Journal of the American Academy of Dermatology, vol. 56, no. 2, pp. 181–200, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Paquet and G. E. Piérard, “New insights in toxic epidermal necrolysis (lyells syndrome): clinical considerations, pathobiology and targeted treatments revisited,” Drug Safety, vol. 33, no. 3, pp. 189–212, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Downey, C. Jackson, N. Harun et al., “Toxic epidermal necrolysis: review of pathogenesis and management,” Journal of the American Academy of Dermatology, vol. 66, no. 6, pp. 995–1003, 2012. View at Google Scholar
  13. C. Paul, P. Wolkenstein, H. Adle et al., “Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis,” British Journal of Dermatology, vol. 134, no. 4, pp. 710–714, 1996. View at Google Scholar · View at Scopus
  14. P. Paquet and G. E. Pierard, “Toxic epidermal necrolysis: revisiting the tentative link between early apoptosis and late necrosis (Review),” International Journal of Molecular Medicine, vol. 19, no. 1, pp. 3–10, 2007. View at Google Scholar · View at Scopus
  15. P. Paquet, P. Delvenne, and G. E. Piérard, “Drug interactions with normal and TEN epidermal keratinocytes,” Current Drug Safety, vol. 7, no. 5, pp. 352–356, 2012. View at Google Scholar
  16. P. Paquet, A. Nikkels, J. E. Arrese, A. Vanderkelen, and G. E. Pierard, “Macrophages and tumor necrosis factor α in toxic epidermal necrolysis,” Archives of Dermatology, vol. 130, no. 5, pp. 605–608, 1994. View at Publisher · View at Google Scholar · View at Scopus
  17. W. H. Chung, S. I. Hung, J. Y. Yang et al., “Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis,” Nature Medicine, vol. 14, no. 12, pp. 1343–1350, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Paquet, P. Quatresooz, and G. E. Piérard, “Factor-XIIIa-positive dendrocytes in drug-induced toxic epidermal necrolysis (Lyell's syndrome): paradoxical activation in skin and rarefaction in lymph nodes,” Dermatology, vol. 206, no. 4, pp. 374–378, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Paquet, D. de Groote, and G. E. Piérard, “Functionally active macrophage-derived myeloperoxidase in the skin of drug-induced toxic epidermal necrolysis,” Dermatology, vol. 220, no. 3, pp. 201–207, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Tohyama, H. Watanabe, S. Murakami et al., “Possible involvement of CD14+ CD16+ monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis,” British Journal of Dermatology, vol. 166, no. 2, pp. 322–330, 2012. View at Google Scholar
  21. D. Couriel, H. Caldera, R. Champlin, and K. Komanduri, “Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management,” Cancer, vol. 101, no. 9, pp. 1936–1946, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Häusermann, R. B. Walter, J. Halter et al., “Cutaneous graft-versus-host disease: a guide for the dermatologist,” Dermatology, vol. 216, no. 4, pp. 287–304, 2008. View at Google Scholar
  23. M. Mielcarek, P. J. Martin, W. Leisenring et al., “Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation,” Blood, vol. 102, no. 2, pp. 756–762, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. J. V. Schaffer, “The changing face of graft-versus-host disease,” Seminars in Cutaneous Medicine and Surgery, vol. 25, no. 4, pp. 190–200, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Paczesny, D. Hanauer, Y. Sun, and P. Reddy, “New perspectives on the biology of acute GVHD,” Bone Marrow Transplantation, vol. 45, no. 1, pp. 1–11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. H. Yoo, B. S. Park, D. Whitaker-Menezes, R. Korngold, and G. F. Murphy, “Dermal dendrocytes participate in the cellular pathology of experimental acute graft-versus-host disease,” Journal of Cutaneous Pathology, vol. 25, no. 8, pp. 426–434, 1998. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Paquet, J. E. Arrese, Y. Beguin, and G. E. Piérard, “Clinicopathological differential diagnosis of drug-induced toxic epidermal necrolysis (Lyell's syndrome) and acute graft-versus-host reaction,” Current Topics in Pathology, vol. 94, pp. 49–63, 2001. View at Google Scholar · View at Scopus
  28. A. D. Hess, “Modulation of graft-versus-host disease: role of regulatory T lymphocytes,” Biology of Blood and Marrow Transplantation, vol. 12, no. 2, pp. 13–21, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Noguchi, D. Wakita, T. Ohkuri et al., “Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen,” Immunology Letters, vol. 136, no. 2, pp. 146–155, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. V. R. Sharon, T. H. Konia, K. L. Barr et al., “Assessment of the “no eosinophils” rule : are eosinophils truly absent in pityriasis lichenoides, connective tissue disease, and graft-vs-host disease?” Journal of Cutaneous Pathology, vol. 39, no. 4, pp. 413–418, 2012. View at Google Scholar
  31. A. C. Gilliam, D. Whitaker-Menezes, R. Korngold, and G. F. Murphy, “Apoptosis is the predominant form of epithelial target cell injury in acute experimental graft-versus-host disease,” Journal of Investigative Dermatology, vol. 107, no. 3, pp. 377–383, 1996. View at Google Scholar · View at Scopus
  32. D. Whitaker-Menezes, S. C. Jones, T. M. Friedman, R. Korngold, and G. F. Murphy, “An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression,” Biology of Blood and Marrow Transplantation, vol. 9, no. 9, pp. 559–570, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. C. C. Hofmeister, A. Quinn, K. R. Cooke, P. Stiff, B. Nickoloff, and J. L. M. Ferrara, “Graft-versus-host disease of the skin: life and death on the epidermal edge,” Biology of Blood and Marrow Transplantation, vol. 10, no. 6, pp. 366–372, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. J. L. M. Ferrara, K. R. Cooke, T. Teshima et al., “The pathophysiology of graft-versus-host disease,” in Graft-Versus-Host Disease, J. Ferrara, K. Cooke, and H. J. Deeg, Eds., pp. 1–34, Dekker, New York, NY, USA, 2005. View at Google Scholar
  35. Q. Zhan, S. Signoretti, D. Whitaker-Menezes, T. M. Friedman, R. Korngold, and G. F. Murphy, “Cytokeratin15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive antiapoptotic phenotype,” Journal of Investigative Dermatology, vol. 127, no. 1, pp. 106–115, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Kohler, M. R. Hendrickson, N. J. Chao, and B. R. Smoller, “Value of skin biopsies in assessing prognosis and progression of acute graft-versus-host disease,” American Journal of Surgical Pathology, vol. 21, no. 9, pp. 988–996, 1997. View at Publisher · View at Google Scholar · View at Scopus
  37. G. E. Piérard, N. Nikkels-Tassoudji, A. F. Nikkels et al., “Epidermal calprotectin expression in lymphocyte-depleted cutaneous graft-versus-host reaction,” Archives of Argentinos Dermatology, vol. 48, pp. 139–142, 1998. View at Google Scholar
  38. G. E. Pierard, N. Nikkels-Tassoudji, J. E. Arrese, A. F. Nikkels, T. H. Le, and C. P. Franchimont, “L1-protein in incipient lymphocyte-depleted graft-versus-host disease. Expression in keratinocytes and coexpression with factor XIIIa in dermal cells,” Turkish Journal of Dermatopathology, vol. 7, no. 1-2, pp. 10–13, 1998. View at Google Scholar · View at Scopus
  39. T. Hermanns-Lê, P. Paquet, C. Piérard-Franchimont, J. E. Arrese, and G. E. Piérard, “Regulatory function of factor-XIIIa-positive dendrocytes in incipient toxic epidermal necrolysis and graft-versus-host reaction. A hypothesis,” Dermatology, vol. 198, no. 2, pp. 184–186, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. Y. Zhou, M. J. Barnett, and J. K. Rivers, “Clinical significance of skin biopsies in the diagnosis and management of graft-vs-host disease in early postallogeneic bone marrow transplantation,” Archives of Dermatology, vol. 136, no. 6, pp. 717–721, 2000. View at Google Scholar · View at Scopus
  41. D. Heldal, L. Brinch, S. A. Evensen et al., “Skin biopsies for early diagnosis and prognosis of graft-versus-host disease in recipients of allogeneic stem cells from blood or bone marrow,” Bone Marrow Transplantation, vol. 34, no. 4, pp. 345–350, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. A. T. Bridge, R. P. Nelson, J. E. Schwartz, G. W. Mirowski, and S. D. Billings, “Histological evaluation of acute mucocutaneous graft-versus-host disease in nonmyeloablative hematologic stem cell transplants with an observation predicting an increased risk of progression to chronic graft-versus-host disease,” American Journal of Dermatopathology, vol. 29, no. 1, pp. 1–6, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. C. Merle, D. Blanc, M. Flesch et al., “A picture of epidermal necrolysis after hepatic allograft. Etiologic aspects,” Annales of Dermatology and Venereology, vol. 117, no. 9, pp. 635–639, 1990. View at Google Scholar
  44. G. Villada, J. C. Roujeau, C. Cordonnier et al., “Toxic epidermal necrolysis after bone marrow transplantation: study of nine cases,” Journal of the American Academy of Dermatology, vol. 23, no. 5, pp. 870–875, 1990. View at Google Scholar · View at Scopus
  45. H. Takeda, Y. Mitsuhashi, S. Kondo, Y. I. Kato, and K. Tajima, “Toxic epidermal necrolysis possibly linked to hyperacute graft-versus- host disease after allogeneic bone marrow transplantation,” Journal of Dermatology, vol. 24, no. 10, pp. 635–641, 1997. View at Google Scholar · View at Scopus
  46. N. Stone, S. Sheerin, and S. Burge, “Toxic epidermal necrolysis and graft vs. host disease: a clinical spectrum but a diagnostic dilemma,” Clinical and Experimental Dermatology, vol. 24, no. 4, pp. 260–262, 1999. View at Publisher · View at Google Scholar · View at Scopus
  47. F. P. Nestel, K. S. Price, T. A. Seemayer, and W. S. Lapp, “Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor α during graft-versus-host disease,” Journal of Experimental Medicine, vol. 175, no. 2, pp. 405–413, 1992. View at Google Scholar · View at Scopus
  48. T. Hermanns-Lê, P. Paquet, A. F. Nikkels, C. Piérard-Franchimont, and G. E. Piérard, “Prolonged imiquimod treatment and graft-versus-host reaction: histological mimicry in the skin infiltration pattern of the monocyte-macrophage-dendrocyte lineage,” Dermatology, vol. 206, no. 4, pp. 361–365, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. P. Quatresooz, P. Paquet, T. Hermanns-Lê, and G. E. Piérard, “Molecular mapping of factor XIIIa-enriched dendrocytes in the skin (review),” International Journal of Molecular Medicine, vol. 22, no. 4, pp. 403–409, 2008. View at Publisher · View at Google Scholar · View at Scopus