Table of Contents
ISRN Gastroenterology
Volume 2013 (2013), Article ID 656921, 8 pages
http://dx.doi.org/10.1155/2013/656921
Clinical Study

Exploring Anorectal Manometry as a Method to Study the Effect of Locally Administered Ropivacaine in Patients with Ulcerative Colitis

1Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, 141 83 Stockholm, Sweden
2Department of Inflammatory Bowel Diseases, HMQ Sophia Hospital, 114 86 Stockholm, Sweden
3Department of Clinical Science, Innovation and Technology, Karolinska Institutet and IBD Clinical Research Group, Karolinska University Hospital, 141 86 Stockholm, Sweden

Received 20 December 2012; Accepted 9 January 2013

Academic Editors: L. Rodrigo and M. Terashima

Copyright © 2013 Eva Arlander et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. S. C. Rao, C. D. Holdsworth, and N. W. Read, “Symptoms and stool patterns in patients with ulcerative colitis,” Gut, vol. 29, no. 3, pp. 342–345, 1988. View at Google Scholar · View at Scopus
  2. N. A. Chaudhary and S. C. Truelove, “Human colonic motility. A comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome,” Gastroenterology, vol. 54, no. 4, pp. 777–778, 1968. View at Google Scholar · View at Scopus
  3. S. N. Reddy, G. Bazzocchi, S. Chan et al., “Colonic motility and transit in health and ulcerative colitis,” Gastroenterology, vol. 101, no. 5, pp. 1289–1297, 1991. View at Google Scholar · View at Scopus
  4. M. J. G. Farthing and J. E. Lennard Jones, “Sensibility of the rectum to distension and the anorectal distension reflex in ulcerative colitis,” Gut, vol. 19, no. 1, pp. 64–69, 1978. View at Google Scholar · View at Scopus
  5. V. Loening-Baucke, A. M. Metcalf, and S. Shirazi, “Anorectal manometry in active and quiescent ulcerative colitis,” American Journal of Gastroenterology, vol. 84, no. 8, pp. 892–897, 1989. View at Google Scholar · View at Scopus
  6. S. S. C. Rao, N. W. Read, P. A. Davison, J. J. Bannister, and C. D. Holdsworth, “Anorectal sensitivity and responses to rectal distension in patients with ulcerative colitis,” Gastroenterology, vol. 93, no. 6, pp. 1270–1275, 1987. View at Google Scholar · View at Scopus
  7. S. S. C. Rao, N. W. Read, J. A. H. Stobart, W. G. Haynes, S. Benjamin, and C. D. Holdsworth, “Anorectal contractility under basal conditions and during rectal infusion of saline in ulcerative colitis,” Gut, vol. 29, no. 6, pp. 769–777, 1988. View at Google Scholar · View at Scopus
  8. L. Chang, J. Munakata, E. A. Mayer et al., “Perceptual responses in patients with inflammatory and functional bowel disease,” Gut, vol. 47, no. 4, pp. 497–505, 2000. View at Publisher · View at Google Scholar
  9. W. J. Snape Jr., S. A. Matarazzo, and S. Cohen, “Abnormal gastrocolonic response in patients with ulcerative colitis,” Gut, vol. 21, no. 5, pp. 392–396, 1980. View at Google Scholar · View at Scopus
  10. W. J. Snape Jr., R. Williams, and P. E. Hyman, “Defect in colonic smooth muscle contraction in patients with ulcerative colitis,” American Journal of Physiology, vol. 261, no. 6, Part 1, pp. G987–G991, 1991. View at Google Scholar · View at Scopus
  11. M. S. Youle and N. W. Read, “Effect of painless rectal distension on gastrointestinal transit of solid meal,” Digestive Diseases and Sciences, vol. 29, no. 10, pp. 902–906, 1984. View at Google Scholar · View at Scopus
  12. E. Arlander, J. Sjovall, J. Sorstad, C. Norsten-Hoog, and L. L. Gustafsson, “Rectal ropivacaine is absorbed proportionally to the dose, with low intraindividual variability,” British Journal of Clinical Pharmacology, vol. 55, no. 1, pp. 14–22, 2003. View at Publisher · View at Google Scholar
  13. E. Arlander, A. Ost, D. Ståhlberg, and R. Löfberg, “Ropivacaine gel in active distal ulcerative colitis and proctitis—a pharmacokinetic and exploratory clinical study,” Alimentary Pharmacology and Therapeutics, vol. 10, no. 1, pp. 73–81, 1996. View at Google Scholar · View at Scopus
  14. I. Cederholm, G. Briheim, H. Rutberg, and C. Dahlgren, “Effects of five amino-amide local anaesthetic agents on human polymorphonuclear leukocytes measured by chemiluminescence,” Acta Anaesthesiologica Scandinavica, vol. 38, no. 7, pp. 704–710, 1994. View at Google Scholar · View at Scopus
  15. T. Martinsson, “Ropivacaine inhibits serum-induced proliferation of colon adenocarcinoma cells in vitro,” Journal of Pharmacology and Experimental Therapeutics, vol. 288, no. 2, pp. 660–664, 1999. View at Google Scholar · View at Scopus
  16. T. Martinsson, A. Haegerstrand, and C. J. Dalsgaard, “Ropivacaine and lidocaine inhibit proliferation of non-transformed cultured adult human fibroblasts, endothelial cells and keratinocytes,” Agents and Actions, vol. 40, no. 1-2, pp. 78–85, 1993. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Martinsson, A. Haegerstrand, and C. J. Dalsgaard, “Effects of ropivacaine on eicosanoid release from human granulocytes and endothelial cells in vitro,” Inflammation Research, vol. 46, no. 10, pp. 398–403, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Martinsson, T. Oda, E. Fernvik, K. Roempke, C. J. Dalsgaard, and E. Svensjö, “Ropivacaine inhibits leukocyte rolling, adhesion and CD11b/CD18 expression,” Journal of Pharmacology and Experimental Therapeutics, vol. 283, no. 1, pp. 59–65, 1997. View at Google Scholar · View at Scopus
  19. T. Martinsson, T. Ljung, C. Rubio, and P. M. Hellstrom, “Beneficial effects of ropivacaine in rat experimental colitis,” Journal of Pharmacology and Experimental Therapeutics, vol. 291, no. 2, pp. 642–647, 1999. View at Google Scholar · View at Scopus
  20. N. E. Diamant, M. A. Kamm, A. Wald, and W. E. Whitehead, “AGA technical review on anorectal testing techniques,” Gastroenterology, vol. 116, no. 3, pp. 735–760, 1999. View at Google Scholar · View at Scopus
  21. M. R. B. Keighley, M. M. Henry, D. C. C. Bartolo, and N. J. M. Mortensen, “Anorectal physiology measurement: report of a working party,” British Journal of Surgery, vol. 76, no. 4, pp. 356–357, 1989. View at Google Scholar · View at Scopus
  22. H. Mertz, B. Naliboff, J. Munakata, N. Niazi, and E. A. Mayer, “Altered rectal perception is a biological marker of patients with irritable bowel syndrome,” Gastroenterology, vol. 109, no. 1, pp. 40–52, 1995. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Geboes, R. Riddell, A. Ost, B. Jensfelt, T. Persson, and R. Löfberg, “A reproducible grading scale for histological assessment of inflammation in ulcerative colitis,” Gut, vol. 47, no. 3, pp. 404–409, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. S. M. Collins, “The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders,” Gastroenterology, vol. 111, no. 6, pp. 1683–1699, 1996. View at Google Scholar · View at Scopus
  25. V. Loening-Baucke, A. M. Metcalf, and S. Shirazi, “Rectosigmoid motility in patients with quiescent and active ulcerative colitis,” American Journal of Gastroenterology, vol. 84, no. 1, pp. 34–39, 1989. View at Google Scholar · View at Scopus
  26. S. S. C. Rao, R. Hatfield, E. Soffer, S. Rao, J. Beaty, and J. L. Conklin, “Manometric tests of anorectal function in healthy adults,” American Journal of Gastroenterology, vol. 94, no. 3, pp. 773–783, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Azpiroz, P. Enck, and W. E. Whitehead, “Anorectal functional testing: review of collective experience,” American Journal of Gastroenterology, vol. 97, no. 2, pp. 232–240, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. S. S. C. Rao, F. Azpiroz, N. Diamant, P. Enck, G. Tougas, and A. Wald, “Minimum standards of anorectal manometry,” Neurogastroenterology and Motility, vol. 14, no. 5, pp. 553–559, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. S. S. C. Rao, N. W. Read, C. Brown, C. Bruce, and C. D. Holdsworth, “Studies on the mechanism of bowel disturbance in ulcerative colitis,” Gastroenterology, vol. 93, no. 5, pp. 934–940, 1987. View at Google Scholar · View at Scopus