Clinical Study

Exploring Anorectal Manometry as a Method to Study the Effect of Locally Administered Ropivacaine in Patients with Ulcerative Colitis

Table 2

Clinical symptoms, endoscopy, and histology scores as recorded before start of treatment (baseline) and after two days and one and four weeks of treatment with 150 mg ropivacaine gel twice daily for four weeks in patients with distal UC.

Time ( )Rectal bleedingRectal painStool consistencyUrgency Summary of clinical symptomsEndoscopyHistology
MedianMin/maxMedianMin/maxMedianMin/maxMedianMin/maxMedianMin/maxMedianMin/maxMedianMin/max

Baseline2.0 2.0/2.01.00.0/2.01.01.0/2.03.02.0/3.09.08.0/10.03.02.0/3.05.05.0/5.0
Day 22.0 1.0/2.01.01.0/1.01.01.0/2.02.01.0/3.08.06.0/9.03.02.0/3.0NP
Week 1*1.50.5/1.51.50.5/2.00.50.5/2.01.01.0/2.08.05.0/9.03.01.0/3.04.53.5/5.0
Week 4 1.01.0/1.01.00.0/1.01.01.0/1.01.00.0/3.07.02.0/9.02.00.0/3.03.02.0/4.0*

, NP: not performed.