Exploring Anorectal Manometry as a Method to Study the Effect of Locally Administered Ropivacaine in Patients with Ulcerative Colitis

Table 3

The volumes required to elicit first sensation, sensation of urgency, maximum filling, and rectoanal inhibitory reflex (RAIR) before start of treatment (baseline) and after two days and one and four weeks of treatment with 150 mg ropivacaine gel twice daily for four weeks in patients with distal UC.

Time (𝑛=7)

Initial sensation

Initial sensation

Sensation urgency

Sensation urgency

Max tolerable

Max tolerable volume

RAIR

(mL)

(mL)

controls (mL)

(mL)

(mL)

volume (mL)

(mL) controls

Median

Min/max

Median

Min/max

Median

Min/max

Median

Min/max

Median

Min/max

Median

Min/max

Baseline

21

9/39

20

7/27

37

30/82

105

29/176

83

72/122

219

156/219

30

30/45

Day 2

20

8/31

43

29/65

59

46/133

30

20/40

Week 1*

18

11/24

48

26/91

68

49/121

30

25/80

Week 4

21

14/33

48

45/52

77

66/96

34

24/40

* 𝑛=6.