Table of Contents
ISRN Nanomaterials
Volume 2013 (2013), Article ID 670402, 5 pages
http://dx.doi.org/10.1155/2013/670402
Research Article

Preparation of AgI/Silica/Poly(Ethylene Glycol) Nanoparticle Colloid Solution and X-Ray Imaging Using It

1Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, 4-12-1 Naka-narusawa-cho, Hitachi, Ibaraki 316-8511, Japan
2Division of Surgical Oncology, Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan

Received 20 June 2013; Accepted 10 July 2013

Academic Editors: T. Maffeis and M.-Q. Zhu

Copyright © 2013 Yoshio Kobayashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This work performed X-ray imaging of mouse by using aqueous colloid solution of AgI nanoparticles coated with silica (AgI/SiO2) and then surface-modified with poly(ethylene glycol) (PEG) (AgI/SiO2/PEG). A colloid solution of AgI nanoparticles was prepared by mixing silver perchlorate and potassium iodide in water. The AgI nanoparticles were surface-modified with 3-mercaptopropyltrimethoxysilane and then were silica-coated by a sol-gel reaction between tetraethylorthosilicate and H2O catalyzed with NaOH in ethanol. The AgI/SiO2 particle surface was modified with PEG by using methoxy PEG silane . The AgI/SiO2/PEG colloid solution revealed a computed tomography value as high as 1343.6 HU at an iodine concentration of 0.1 M, which was higher than a commercial X-ray contrast agent with the same iodine concentration. Tissues of mouse could be imaged by injecting the concentrated colloid solution into them.