Research Article | Open Access
Emily P. Jolles, Raj S. Padwal, Alexander M. Clark, Branko Braam, "A Qualitative Study of Patient Perspectives about Hypertension", International Scholarly Research Notices, vol. 2013, Article ID 671691, 10 pages, 2013. https://doi.org/10.5402/2013/671691
A Qualitative Study of Patient Perspectives about Hypertension
To understand hypertensive patients' perspectives regarding blood pressure and hypertension treatment, this qualitative study applied semistructured interviews of hypertensive patients. Participants were recruited from two hypertension clinics at the University of Alberta in Edmonton, Canada. To be eligible for inclusion, patients had to be aged 18 years or older, diagnosed with hypertension by a healthcare provider, and currently taking an antihypertensive medication. Participants were stratified in the analysis according to blood pressure control. Twenty-six patients (mean age 57; 62% female) were interviewed, of which 42% were on target and 58% were not. Three underlying themes emerged from the interviews: (a) knowledge of blood pressure relating to diagnosis and management and control of hypertension, (b) integration of hypertension management into daily routine, and (c) feelings and beliefs of wellness. None of the above themes were associated with better control. Knowledge gaps were found, which emphasize the need for further patient education and physician training. Feelings and beliefs of wellness, and not knowledge, were important factors in home assessment of blood pressure. The absence of connections between control of hypertension and the identified domains indicates that current approaches could benefit from the development of a more personalized approach for education and communication.
Hypertension is highly prevalent, and although rates of detection and control of hypertension are improving in many countries, uncontrolled hypertension remains common  and medication and lifestyle adherence remains low. Nonadherence leads to substantial avoidable healthcare costs  because of inefficiencies in care delivery, discarded medications, and expenditures related to preventable hypertension-related sequelae . Nonpharmacological interventions to improve hypertensive medication adherence are usually very complex involving both educational and behavioural interventions and data examining efficacy have not been consistent . Improved understanding of the psychology of the hypertensive patient seems desirable.
A number of patient-related barriers to optimizing blood pressure (BP) control have been identified. These include lack of patient knowledge, difficulty of treating an asymptomatic condition, personal beliefs that conflict with hypertension treatment goals, and other patient issues such as social economic status, cultural beliefs, access to care, psychosocial factors, and health literacy . Additional obstacles include a lack of communication and trust between patients and care providers, high medication costs, high drug burden, failure to attend follow-up appointments, and discontinuation of therapy due to drug side effects [5–10]. There is limited data available about patients’ personal perspectives regarding obstacles to hypertension control [11, 12]. We therefore performed a qualitative study consisting of semistructured interviews to explore hypertensive patients’ views on their disease state and issues related to optimizing BP control.
2.1. Patient Recruitment and Inclusion
Patients were recruited from two hypertension clinics at the University of Alberta (Edmonton, Midwestern Canada). Inclusion criteria were age over 18 years; ability to read, speak, and write English; hypertension defined as either having a BP over the desired target, patients' BP was either <140/90 mm Hg or <130/80 mm Hg in case of DM or CKD, or being on antihypertensive therapy; absence of cognitive dysfunction; use of at least one hypertensive drug; agreeing to sign informed consent. Each patient was mailed a pamphlet as part of the appointment scheduling, and, during the appointment, recruiting physicians asked patients whether they would be willing to participate in the study. Written information about the study was then provided by the study coordinator and informed consent was obtained. Patients received a $50 reimbursement for participation in the study for the time spent on the interview and costs of parking and travel. Ethical approval was obtained from the University of Alberta Health and Research Ethics Board; all participating patients signed consent to participate in the study.
2.2. Conducting Qualitative Interviews
Patients were consented and interviewed by EPJ, and all interviews were audio-taped and transcribed verbatim. The interviewer stated that she was interested in patients’ perspective on hypertension management and ensured confidentiality that patients’ answers would not be reported back to the referring doctor. Interviews were conducted in a neutral, nonclinical setting. The sample was substratified according to hypertension control (controlled versus uncontrolled). Patients were considered “on target” if BP was either <140/90 mm Hg or <130/80 mm Hg in case of DM or renal impairment defined by estimated GFR <90 mL/min/1.72 m2 as derived from the MDRD equation.
An interview topic guide was developed using the current literature in the field and based on expert opinion. Interviews were semistructured, 30–60 minutes in duration, and designed to elicit patients’ perspectives using open-ended questions to trigger responses and prompts/probes as necessary for clarification purposes. Two pilot interviews were conducted and transcribed, after which the interview guide was refined, and then the remaining interviews were conducted. The pilot interviews were included in the analysis. Specific interview topics were definitions of high BP, the consequences of uncontrolled hypertension, current BP in relation to targets, methods to lower BP, medication adverse effects, and barriers to and facilitators of routine drug intake and adherence.
Data analysis was organized using NVIVO8 (QSR International), a computer program that organizes repeating themes and aids in the coding of transcripts. Themes were derived from a review of the literature and by cataloguing reoccurring themes from the interviews . Additionally, descriptive statistics such as lab values and demographic variables were extracted from charts and added to the dataset for analysis. To ensure rigour, a selection of early transcripts was reviewed independently by 2 researchers (E. P. Jolles and A. M. Clark). Themes emerging from the interviews were used to create categories and subcategories for the coding framework. Interviews were conducted until data saturation was reached and new themes were no longer emerging.
3.1. Patient Population
Twenty-six patients (62% female; majority Caucasian), aged years (range 26–84), were included in analysis. Baseline characteristics are provided in Table 1. Sixty-five percent of the participants were prescribed more than one drug for hypertension. The most commonly prescribed antihypertensive drug class was inhibitors of the renin-angiotensin system (62%). Forty-two percent of the patients were at or below target BP levels.
| patient’s information not available.|
3.2. Qualitative Interviews
Three underlying themes emerged from the interviews: knowledge of BP, management integration of hypertension management into the daily routine, and individual patient feelings and beliefs of wellness that impact hypertension control (Figure 1). Detailed themes mentioned most often by patients are listed in Table 2 and are stratified by patients on and off target.
3.3. Knowledge about Hypertension
Patients widely reported that hypertension was a health concern to them. However, while patients possessed some general knowledge of their condition and hypertension, the level and sophistication of this knowledge varied widely (Table 3). About half (54%) of patients were able to recall that optimal BP was 120/80 mm Hg or could identify their target BP threshold (<140/90 mm Hg and <130/80 mm Hg for those with DM or CKD). Neither patient sex nor achieved BP levels were related to knowledge about targets. However, most patients (92%) were aware of methods that could or would be likely to lower their BP. The majority (92%) knew their current BP. Seventy-three percent of patients could recall consequences of hypertension, such as cardiovascular events and renal disease, but patients struggled to define hypertension.
Patients indicated that healthcare providers did communicate information about hypertension; however, around half of patients had additional questions. Some patients perceived that their doctors were “too busy” to answer additional questions. Patients (69%) mentioned that other healthcare providers, such as pharmacists and specialists, often provided more education than physicians.
3.4. Knowledge about Antihypertensive Medication
When asked about the function of medication, most patients did not know the exact mechanism of action of the pills. The consistent exception to this was diuretics, which patients referred to as a “water pill.” Patients described the water pill as “flushing the system instead of building up,” “makes you pee more,” and “takes certain things out of your system like sodium and different things out of your blood stream.” All patients viewed their BP medication as being all quite similar (i.e., did not believe that one was more “powerful” or “important” than another).
More than half of patients (69%) attributed health issues to side effects from their antihypertensive medication. Patients stated that they were comfortable and quick to discuss adverse effects with their doctor so that medication could be changed. The most commonly perceived side effects were edema (19%), dizziness (19%), increased urination (15%), headaches (12%), dry throat/cough (8%), nausea and vomiting (8%), loss of sexual desire (8%), feeling lethargic (8%), heartburn (4%), hair loss (4%), and constipation (4%).
3.5. Knowledge Regarding Lifestyle
Patients understood that lifestyle modifications could decrease BP. The majority of patients (85%) mentioned changes such as reducing salt intake and checking for sodium content (88%), exercising (69%), following a healthier diet (eating more fruits and vegetables) (69%), losing weight (46%), decreasing stress (38%), quitting smoking (12%), decreasing caffeine intake (8%), and lowering alcohol intake (4%). While quitting smoking does not decrease BP (CHEP 2011 guidelines), smokers did state that among ways to lower BP, quitting smoking would be relevant. Surprisingly, few patients (12%) indicated that incomplete adherence to lifestyle modification advice was preventing them from decreasing medications.
3.6. Pragmatism and Routines: Integration of Medication into Daily Life
The most frequently mentioned barrier to medication adherence was a lack of a structured routine or a change in the existing routine (88% mentioned routine) for self-administering BP medications (Table 4). Patients reported greatest success when they were able to seamlessly integrate their medication into their daily life. Patients had difficulty when schedules and routines were interrupted unless they had coping strategies to deal with these issues (e.g., carrying around extra pills and traveling with pill boxes). Of the 81% of respondents that commented on missed doses, 54% denied missing any dose and 27% reported that they “sometimes” missed a dose either due to forgetting or a change in routine. When asked what would happen if a dose was missed, respondents reported that they would take the next scheduled dose (and by doing so, they would miss a dose). Additionally, some stated that they may experience some side effects (headache, BP fluctuations, and feeling tired) from a missed dose. Monetary issues were only cited by 8% of patients.
Facilitators of adherence included having an established routine and using reminder tools to ensure medication is taken on a daily basis. Almost all patients (88%) mentioned that using day-labeled pill boxes and making pills visible, along with establishing a routine that incorporates drug administration, ensured daily adherence. This could be summarized by one patient: “… Wash your face, brush your teeth, and take your pills” (male, on target). Patients described additional strategies to optimize adherence including pill counting prior to embarking on a trip and carrying special traveling boxes for extra pills in case that some were lost or misplaced. Lastly, 12% of patients mentioned that spouses and family members helped remind them to take their pills and refill their prescriptions.
3.7. Integration of Exercise and Diet Routine: Barriers and Facilitators
Barriers to maintain a healthy diet were mentioned by 58% of respondents (work schedule, too busy to cook, frequently eating out/prepared meals, lack of routine or motivation, and costs) and 38% mentioned facilitators (spouse support, use of precut fresh foods and salt-free foods, label reading, time management, and creating a routine) for healthy eating. Exercise barriers (weather, disability/injury, time/busy, lack of energy, lack of motivation or routine, and lack of social support) were mentioned by 54% of patients, while only 19% mentioned facilitators for increasing activity levels (exercise equipment or video games in home and better weather). Thoughts about being overweight were expressed by 50% of the patients (63% of females and 30% of males).
3.8. Feelings and Beliefs of Wellness
Despite hypertension often being described as being “silent” and asymptomatic, 69% of participants experienced symptoms that they attributed to elevated BP levels (Table 5) so that personal feelings and/or beliefs had an impact on hypertension management. Patients mentioned physical manifestations such as headaches (38%), loss of energy, feelings of weakness/tiredness (27%), dizziness and light-headedness (19%), water retention (19%), and numbness (8%). Thirty-one percent of the respondents felt that these symptoms were associated with fluctuations in their BP levels and appeared when their BP was not controlled. Participants used these symptoms as an indication of whether or not a BP measurement should be taken or a care provider seen. Others were motivated to improve their BP control because of fear of worsening symptoms or because of a positive family history. The majority of patients owned a BP machine (85%) for home monitoring or would go to the drugstore for regular testing.
Over half of patients (62%) mentioned that they wanted to reduce their antihypertensive pill burden or discontinue pills altogether. Twenty-three percent of the respondents reported trying nontraditional approaches and remedies before conventional drug therapy because they either did not want to take prescribed pills or felt there were “more natural ways” to lower BP.
This study explored barriers to and facilitators of hypertension management from the patients’ perspective by using semistructured interviews. Three recurrent themes were identified: knowledge, routines, and personal beliefs and feelings of wellness. Paradoxically, more knowledge about BP and its treatment was not associated with better control. Patients recognized the importance of routines for medication adherence; yet, they ascribed many symptoms to the side effects of drugs. Interestingly, physical and psychological factors were interpreted to be reflecting the prevailing BP level.
As mentioned, knowledge did not correlate with BP control in this study. This was remarkable, considering that the recruited patients were from specialist hypertension clinics, which distribute educational materials at the time of the appointment regarding optimal BP levels, home monitoring, lifestyle changes, and ways to lower BP. Other studies reported similar findings in regard to BP target knowledge and recall of information [14–16]. Knowledge regarding consequences of lifestyle changes and mechanisms of antihypertensive medication was not associated with control of hypertension. Similarly, an intensive nutritional intervention therapy (intense one-on-one educational sessions) for hypertensive patients increased knowledge but was not associated with improved dietary behaviour . In summary, patient education can lead to increased knowledge about hypertension; however, this is not necessarily reflected in adaptations in behaviour  or, as this study shows, is not associated with better BP control.
Knowledge by itself may not impact adherence, but perhaps it is the way that knowledge is presented together with patient-related factors such as personal beliefs. For instance, patients mentioned that incomplete adherence to lifestyle modification was preventing them from reducing their pill burden. This indicates that patients are aware of the impact of lifestyle modifications, however, failed to translate this into implementation. Knowledge has been shown to enhance behaviour changes  in some studies but to a limited extent. Rigorous programs for behaviour change have shown improvements in patient BP. Self-management education interventions showed benefit for systolic BP , and intensive lifestyle medication in primary care showed a small reduction of BP . Paradoxically, the absence of knowledge can potentially help adherence in that passive followers (those that do as the doctor tells them to do) may adhere better to medication. One study suggested that some patients adhere to medications simply because they generally follow rules (the study compared this to wearing a seat belt in the rear of the car ), or perhaps patients have trust in their doctor and medical plan . On the contrary, patients without complete knowledge may have decreased adherence due to this lack of knowledge, along with personal beliefs that may conflict with management. In summary, it seems that individual patient factors and beliefs may act as barriers to applying knowledge, which underscores our limited insight in how to improve adherence to antihypertensive treatment.
A lack of a routine for medication use was the most frequently reported barrier to proper BP control. The presence of an established routine was identified as a key facilitator of achieving control. While not extensively described in the literature, habits and routine can impact management of hypertension . The initiation of a routine to improve chronic disease management can be difficult for some because habits/routines that have been in place for years must be changed . Complications arise further when multiple changes must occur. One study reported that patients were adherent to one piece of advice, however, had difficulties in simultaneously adhering to several medications and several lifestyle and monitoring changes . Patients reported that disruption of routine, such as travel, in addition to interruptions of daily routines impaired adherence to medication and healthy lifestyle behaviours. When asked about daily medication adherence, the majority of patients denied missing a dose, and this finding that patients often overstate adherence in comparison to pharmacy refill data has been previously described in the literature . In addition, adherence to lifestyle changes can be difficult for patients to integrate into daily life. Failure can be attributed to time constraints, lack of motivation, fatigue, cost, and a lack of motivation to make changes; prior data demonstrates that about 50% of patients have difficulties implementing diet and exercise [27, 28]. While the majority of patients recognized that taking antihypertensive medicine was beneficial to their health, many were not at target BP levels, which suggest that patients’ knowledge and disease awareness are not sufficient on their own to optimize BP control. Facilitators can significantly increase adherence, in addition to coping skills to assist with taking pills, reminders, and adhering to lifestyle changes. Ultimately, as seen from our study and current literature, routine is only one necessary part of medication adherence, however, a strong indicator of whether or not patients adhere to both medication and lifestyle changes for management of hypertension, over any other factors that were mentioned by patients. Patients with routine and the coping skills to adapt to changes in routine may fare best with medication adherence and maintaining lifestyle changes. One limitation to the current study is that we are unaware of how many patients actively used “routine” for their HTN management, or if routine was already a part of everyday life.
Our study reveals that patients’ feelings and beliefs of wellness can impact adherence to physician recommendations of daily medication and lifestyle changes. Despite clinical literature that describes hypertension as asymptomatic, our findings are consistent with other qualitative studies where patients describe physical symptoms of hypertension . It should be remarked that this observation does not provide evidence to state that hypertensive patients have specific complaints that differ from a group of healthy age-matched subjects. Yet, it has relevance. As indicated by our data, we found that those patients who experienced negative effects associated with hypertension also believed that their BPs were higher. Patients used the way they feel and their perceptions of their health to self-monitor their BP and to determine BP actions (take a BP measurement, consume medication, or go to the hospital). Obviously, this is not desirable, although for some this may support adherence and serve as motivation to adhere to medication. However, for others who believe that hypertension is symptomatic and who do not experience physical symptoms, such beliefs may interfere with adherence to medical advice and with home assessment of BP . This observation has obvious consequences for patient education.
Perception of disease is important as well. In a study of hypertensive patients, those that rated their overall health as good/excellent were less likely to have controlled hypertension, along with those younger (<45 years) and those unaware of family history . About 75% of patients in our study mentioned benefits to taking the medications; however, this was not related to BP control. One study suggests that patients may attribute the effectiveness of their medications to their overall sense of well-being and/or the presence or absence of physical symptoms . Beliefs can depend on patient characteristics, psychological factors , sociocultural context , and values . Altogether the role of patient feelings and beliefs of wellness may have a very substantial impact on adherence and could be a strong indicator regarding the intention to change behaviour.
Summarizing, we identified several individual patient issues relevant to the treatment of hypertension. Patient knowledge, routines, and beliefs about their health could interfere with hypertension management. This suggests combining educational materials with more intense behavioural modifications, including coping and changes in routine, and incorporating principles of health literacy and cultural competence could bring benefit to hypertension management. Lastly, the role of the provider is “the most important interaction in ensuring adequate medication adherence” , which could play a role in the patients’ belief system. Building upon the existing research to develop an instrument to assess patients’ personal barriers could have widespread relevance for better control of BP.
The authors would like to thank the patients who participated in this study and Ms. Melisa Spaling for her input and suggestions for the paper. The Department of Medicine and Alberta Health Services supported this study (Emerging Team Grant). Dr. Braam is a Heart and Stroke Foundation of Canada New Investigator.
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