Table 4: Comparative analysis of thyroid nodules and thyroid carcinoma between patients with Graves’ disease and Hashimoto’s thyroiditis.

Graves’ diseaseHashimoto's thyroiditis

Nodules ( = 94)

Gender—male/female (%)4/51 (4.26/54.26)2/37 (2.13/39.36)1
Age—yrs (range)53 (27–84)55 (15–84)0.942
Age at diagnosis—yrs (range)46 (17–81)47 (5–70)0.896
Disease duration—yrs (range)6 (0.6–20)7 (0.2–16)0.911
Total thyroid volume—cc (range)29.8 (4.1–242)18.5 (1–111.9)0.002
PTC (%)9 (9.57)6 (6.38)0.898
US echogenicity—hyper/iso/hypo (%)12/28/9 (13.95/32.56/10.47)4/19/14 (4.65/22.09/16.28)0.073
Time of followup—yrs (range)6 (0.3–20)7 (0.2–16)0.661
Smoking (%)a18 (31.58)9 (15.79)0.439
Time of treatment—yrs (range)4 (0.3–17)6 (1–16)0.001
Number of nodules (range)2 (1–7)2 (1–6)0.861
Size of largest nodule on US—cm (range)1.7 (0.5–6.8)1.6 (0.5–4.6)0.575

PTC ( = 16)

Gender—male/female (%)1/9 (6.25/56.25)0/6 (0/37.5)0.95
Age—yrs (range)39 (28–58)55 (51–84)0.019
Age at diagnosis—yrs (range)30 (17–49)49 (44–70)0.004
Disease duration—yrs (range)9 (3–18)8.5 (2–14)0.786
Total thyroid volume—cc (range)55.1 (16.2–167.5)26.7 (6.4–111.9)0.357
PTC (%)10 (62.5)6 (37.5)0.751
US echogenicity—hyper/iso/hypo (%)b3/5/0 (21.43/35.71/0)0/2/4 (0/14.29/28.57)0.019
Microcarcinoma (%)3 (18.75)1 (6.25)1
Histopathological variant—classical/follicular (%)4/6 (25/37.5)4/2 (25/12.5)0.608
Multifocal (%)4 (25)2 (12.5)1
Time of followup—yrs (range)9 (3–18)8.5 (3–14)0.785
Smoking (%)4 (25)1 (6.25)0.588
Time of treatment—yrs (range)3.5 (1–6)7 (2–14)0.062
Number of nodules (range)1.5 (0–5)3 (1–5)0.148
Size of largest nodule on US—cm (range)2.2 (0.5–6.8)2.1 (1–4.3)0.796

a = 57.
b = 14.