Table of Contents
ISRN Gastroenterology
Volume 2013 (2013), Article ID 679724, 7 pages
http://dx.doi.org/10.1155/2013/679724
Research Article

Loss of Villin Immunoexpression in Colorectal Carcinoma Is Associated with Poor Differentiation and Survival

1Scientific Chair for Colorectal Cancer, King Abdulaziz University, P.O. Box 80205, Jeddah 21589, Saudi Arabia
2Department of Pathology, King Abdulaziz University, P.O. Box 80205, Jeddah 21589, Saudi Arabia
3Center of Excellence in Genomic Medicine Research, King Abdulaziz University, P.O. Box 80205, Jeddah 21589, Saudi Arabia
4Department of Pathology, Faculty of Medicine, Minia University, El Minia, Egypt
5Department of Medicine, King Abdulaziz University, P.O. Box 80205, Jeddah 21589, Saudi Arabia

Received 9 June 2013; Accepted 29 June 2013

Academic Editors: A. Amedei and A. J. Karayiannakis

Copyright © 2013 Jaudah Al-Maghrabi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. W. Huh, H. R. Kim, Y. J. Kim et al., “Expression of standard CD44 in human colorectal carcinoma: association with prognosis,” Pathology International, vol. 59, no. 4, pp. 241–246, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Kunimura, T. Yoshida, T. Sugiyama, and T. Morohoshi, “The relationships between loss of standard CD44 expression and lymph node, liver metastasis in T3 colorectal carcinoma,” Journal of Gastrointestinal Cancer, vol. 40, no. 3-4, pp. 115–118, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Al-Eid and S. Arteh, “Cancer Incidence Report Saudi Arabia,” 1–99, 2005.
  4. R. Athman, D. Louvard, and S. Robine, “The epithelial cell cytoskeleton and intracellular trafficking III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?” American Journal of Physiology, vol. 283, no. 3, pp. G496–G502, 2002. View at Google Scholar · View at Scopus
  5. A. Bretscher and K. Weber, “Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner,” Cell, vol. 20, no. 3, pp. 839–847, 1980. View at Google Scholar · View at Scopus
  6. D. Arango, S. Al-Obaidi, D. S. Williams et al., “Villin expression is frequently lost in poorly differentiated colon cancer,” American Journal of Pathology, vol. 180, no. 4, pp. 1509–1521, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Khurana and S. P. George, “Regulation of cell structure and function by actin-binding proteins: villin's perspective,” FEBS Letters, vol. 582, no. 14, pp. 2128–2139, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. C. E. Bacchi and A. M. Gown, “Distribution and pattern of expression of villin, a gastrointestinal-associated cytoskeletal protein, in human carcinomas: a study employing paraffin-embedded tissue,” Laboratory Investigation, vol. 64, no. 3, pp. 418–424, 1991. View at Google Scholar · View at Scopus
  9. R. Moll, S. Robine, B. Dudouet, and D. Louvard, “Villin: a cytoskeletal protein and a differentiation marker expressed in some human adenocarcinomas,” Virchows Archiv B, vol. 54, no. 3, pp. 155–169, 1987. View at Google Scholar · View at Scopus
  10. P. J. Zhang, K. R. Harris, B. Alobeid, and J. J. Brooks, “Immunoexpression of villin in neuroendocrine tumors and its diagnostic implications,” Archives of Pathology and Laboratory Medicine, vol. 123, no. 9, pp. 812–816, 1999. View at Google Scholar · View at Scopus
  11. V. Subramaniam, I. R. Vincent, H. Gardner, E. Chan, H. Dhamko, and S. Jothy, “CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation,” Experimental and Molecular Pathology, vol. 83, no. 2, pp. 207–215, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Wang, K. Srinivasan, M. R. Siddiqui, S. P. George, A. Tomar, and S. Khurana, “A novel role for villin in intestinal epithelial cell survival and homeostasis,” The Journal of Biological Chemistry, vol. 283, no. 14, pp. 9454–9464, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Yoshino, H. Kubokura, S. Yamauchi, Y. Ohaki, K. Koizumi, and K. Shimizu, “Mucinous carcinoma identified as lung metastasis from an early rectal cancer with submucosal invasion by immunohistochemical detection of villin,” Japanese Journal of Thoracic and Cardiovascular Surgery, vol. 54, no. 8, pp. 328–331, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Athman, M.-I. Fernandez, P. Gounon et al., “Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells,” Cellular Microbiology, vol. 7, no. 8, pp. 1109–1116, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Tomar, Y. Wang, N. Kumar et al., “Regulation of cell motility by tyrosine phosphorylated villin,” Molecular Biology of the Cell, vol. 15, no. 11, pp. 4807–4817, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Al-Muhannadi, N. Ansari, U. Brahmi, and A. A. Satir, “Differential diagnosis of malignant epithelial tumours in the liver: an immunohistochemical study on liver biopsy material,” Annals of Hepatology, vol. 10, no. 4, pp. 508–515, 2011. View at Google Scholar · View at Scopus
  17. S. K. Lau, S. Prakash, S. A. Geller, and R. Alsabeh, “Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma,” Human Pathology, vol. 33, no. 12, pp. 1175–1181, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. H.-J. Grone, K. Weber, U. Helmchen, and M. Osborn, “Villin—a marker of brush border differentiation and cellular origin in human renal cell carcinoma,” American Journal of Pathology, vol. 124, no. 2, pp. 294–302, 1986. View at Google Scholar · View at Scopus
  19. E. Pringault, M. Arpin, A. Garcia, J. Finidori, and D. Louvard, “A human villin cDNA clone to investigate the differentiation of intestinal and kidney cells in vivo and in culture,” EMBO Journal, vol. 5, no. 12, pp. 3119–3124, 1986. View at Google Scholar · View at Scopus
  20. Y. Nambu, M. D. Iannettoni, M. B. Orringer, and D. G. Beer, “Unique expression patterns and alterations in the intestinal protein villin in primary and metastatic pulmonary adenocarcinomas,” Molecular Carcinogenesis, vol. 23, pp. 234–242, 1998. View at Google Scholar
  21. R. W. Werling, H. Yaziji, C. E. Bacchi, and A. M. Gown, “CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas,” American Journal of Surgical Pathology, vol. 27, no. 3, pp. 303–310, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Tan, G. Sidhu, M. A. Greco, H. Ballard, and R. Wieczorek, “Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets,” Human Pathology, vol. 29, no. 4, pp. 390–396, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. A. B. West, C. A. Isaac, J. M. Carboni, J. S. Morrow, M. S. Mooseker, and K. W. Barwick, “Localization of villin, a cytoskeletal protein specific to microvilli, in human ileum and colon and in colonic neoplasms,” Gastroenterology, vol. 94, no. 2, pp. 343–352, 1988. View at Google Scholar · View at Scopus
  24. S. Kersting, M. Bruewer, G. Schuermann et al., “Antigen transport and cytoskeletal characteristics of a distinct enterocyte population in inflammatory bowel diseases,” American Journal of Pathology, vol. 165, no. 2, pp. 425–437, 2004. View at Google Scholar · View at Scopus
  25. N. Yamamichi, K.-I. Inada, C. Furukawa et al., “Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells,” Experimental Cell Research, vol. 315, no. 10, pp. 1779–1789, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. R. A. D. Louvard and S. Robine, “Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells,” Molecular Biology of the Cell, vol. 14, no. 11, pp. 4641–4653, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Khurana, A. Tomar, S. P. George et al., “Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia,” Experimental Cell Research, vol. 314, no. 3, pp. 530–542, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Tomar, S. George, P. Kansal, Y. Wang, and S. Khurana, “Interaction of phospholipase C-γ1 with villin regulates epithelial cell migration,” The Journal of Biological Chemistry, vol. 281, no. 42, pp. 31972–31986, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Wang, A. Tomar, S. P. George, and S. Khurana, “Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration,” American Journal of Physiology, vol. 292, pp. C1775–C1786, 2007. View at Google Scholar