Table of Contents
ISRN Oncology
Volume 2013, Article ID 684026, 8 pages
http://dx.doi.org/10.1155/2013/684026
Clinical Study

Epidemiology and Prognosis of Paraneoplastic Syndromes in Hepatocellular Carcinoma

1Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore 169608
2Gleneagles Hospital, Singapore 258500

Received 25 June 2013; Accepted 10 September 2013

Academic Editors: J. Bentel, B. Comin-Anduix, G. Metro, and C.-x. Pan

Copyright © 2013 Pik Eu Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Bosetti, F. Levi, P. Boffetta, F. Lucchini, E. Negri, and C. La Vecchia, “Trends in mortality from hepatocellular carcinoma in Europe, 1980–2004,” Hepatology, vol. 48, no. 1, pp. 137–145, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. R. B. Goldberg, I. Bersohn, and M. C. Kew, “Hypercholesterolaemia in primary cancer of the liver,” South African Medical Journal, vol. 49, no. 36, pp. 1464–1466, 1975. View at Google Scholar · View at Scopus
  3. M. Sorlini, F. Benini, P. Cravarezza, and G. Romanelli, “Hypoglycemia, an atypical early sign of hepatocellular carcinoma,” Journal of Gastrointestinal Cancer, vol. 41, no. 3, pp. 209–211, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. W. A. Oldenburg, J. A. Van Heerden, and G. W. Sizemore, “Hypercalcemia and primary hepatic tumors,” Archives of Surgery, vol. 117, no. 10, pp. 1363–1366, 1982. View at Google Scholar · View at Scopus
  5. P. E. Chang and C. K. Tan, “Paraneoplastic erythrocytosis as a primary presentation of hepatocellular carcinoma,” Indian Journal of Medical Sciences, vol. 63, no. 5, pp. 202–203, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Walcher, T. Witter, and H. D. Rupprecht, “Hepatocellular carcinoma presenting with paraneoplastic demyelinating polyneuropathy and PR3-antineutrophil cytoplasmic antibody,” Journal of Clinical Gastroenterology, vol. 35, no. 4, pp. 364–365, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. M. R. Arguedas and B. M. McGuire, “Hepatocellular carcinoma presenting with chronic inflammatory demyelinating polyradiculoneuropathy,” Digestive Diseases and Sciences, vol. 45, no. 12, pp. 2369–2373, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Hinterhuber, J. Drach, E. Riedl et al., “Paraneoplastic pemphigus in association with hepatocellular carcinoma,” Journal of the American Academy of Dermatology, vol. 49, no. 3, pp. 538–540, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Coeytaux, R. Kressig, and G. B. Zulian, “Hepatocarcinoma with concomitant paraneoplastic encephalomyelitis,” Journal of Palliative Care, vol. 17, no. 1, pp. 59–60, 2001. View at Google Scholar · View at Scopus
  10. S. J. Hwang, J. C. Luo, C. P. Li et al., “Thrombocytosis: a paraneoplastic syndrome in patients with hepatocellular carcinoma,” World Journal of Gastroenterology, vol. 10, no. 17, pp. 2472–2477, 2004. View at Google Scholar · View at Scopus
  11. J. C. Luo, S. J. Hwang, J. C. Wu et al., “Paraneoplastic syndromes in patients with hepatocellular carcinoma in Taiwan,” Cancer, vol. 86, pp. 799–804, 1999. View at Publisher · View at Google Scholar
  12. J. C. Luo, S. J. Hwang, J. C. Wu et al., “Clinical characteristics and prognosis of hepatocellular carcinoma patients with paraneoplastic syndromes,” Hepato-Gastroenterology, vol. 49, no. 47, pp. 1315–1319, 2002. View at Google Scholar · View at Scopus
  13. U. Y. Huh, J. H. Kim, B. H. Kim et al., “The incidence and clinical significance of paraneoplastic syndromes in patients with hepatocellular carcinoma,” The Korean Journal of Hepatology, vol. 11, no. 3, pp. 275–283, 2005 (Korean). View at Google Scholar · View at Scopus
  14. D. A. Ndububa, S. O. Olusegun, V. A. Adetiloye, O. Rotimi, M. A. Durosinmi, and L. O. Uchegbu, “The incidence and characteristics of some paraneoplastic syndromes of hepatocellular carcinoma in Nigerian patients,” European Journal of Gastroenterology and Hepatology, vol. 11, no. 12, pp. 1401–1404, 1999. View at Google Scholar · View at Scopus
  15. S. O. Teniola and I. O. Ogunleye, “Paraneoplastic syndromes in primary liver cell carcinoma in Nigeria,” Tropical and Geographical Medicine, vol. 46, no. 1, pp. 20–22, 1994. View at Google Scholar · View at Scopus
  16. C. W. Chu, S. J. Hwang, J. C. Luo et al., “Manifestations of hypercholesterolaemia, hypoglycaemia, erythrocytosis and hypercalcaemia in patients with hepatocellular carcinoma: report of two cases,” Journal of Gastroenterology and Hepatology, vol. 14, no. 8, pp. 807–810, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Attali, D. Houssin, and A. Roche, “Hepatic arterial embolization for malignant hypercalcemia in hepatocellular carcinoma,” Digestive Diseases and Sciences, vol. 29, no. 5, pp. 466–469, 1984. View at Google Scholar · View at Scopus
  18. E. J. Mahoney, J. M. Monchik, G. Donatini, and R. De Lellis, “Life-threatening hypercalcemia from a hepatocellular carcinoma secreting intact parathyroid hormone: localization by sestamibi single-photon emission computed tomographic imaging,” Endocrine Practice, vol. 12, no. 3, pp. 302–306, 2006. View at Google Scholar · View at Scopus
  19. M. W. Ghobrial, J. George, S. Mannam, and S. R. Henien, “Severe hypercalcemia as an initial presenting manifestation of hepatocellular carcinoma,” Canadian Journal of Gastroenterology, vol. 16, no. 9, pp. 607–609, 2002. View at Google Scholar · View at Scopus
  20. P. Tudela, B. Soldevila, J. M. Mòdol, and E. Domènech, “Hypercalcemic encephalopathy in a patient with hepatocellular carcinoma,” Digestive Diseases and Sciences, vol. 52, no. 11, pp. 3296–3297, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. A. M. Leichtner, M. Krieger, and A. L. Schwartz, “Regulation of low density lipoprotein receptor function in a human hepatoma cell line,” Hepatology, vol. 4, no. 5, pp. 897–901, 1984. View at Google Scholar · View at Scopus
  22. T. Sohda, K. Iwata, Y. Kitamura et al., “Reduced expression of low-density lipoprotein receptor in hepatocellular carcinoma with paraneoplastic hypercholesterolemia,” Journal of Gastroenterology and Hepatology, vol. 23, no. 7, pp. e153–e156, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Kawata, K. Takaishi, T. Nagase et al., “Increase in the active form of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human hepatocellular carcinoma: possible mechanism for alteration of cholesterol biosynthesis,” Cancer Research, vol. 50, no. 11, pp. 3270–3273, 1990. View at Google Scholar · View at Scopus
  24. S. J. Hwang, S. D. Lee, C. F. Chang et al., “Hypercholesterolaemia in patients with hepatocellular carcinoma,” Journal of Gastroenterology and Hepatology, vol. 7, no. 5, pp. 491–496, 1992. View at Google Scholar · View at Scopus
  25. A. J. McFadzean, D. Todd, and K. C. Tsang, “Polycythemia in primary carcinoma of the liver,” Blood, vol. 13, no. 5, pp. 427–435, 1958. View at Google Scholar · View at Scopus
  26. S. Sakisaka, M. Watanabe, H. Tateishi et al., “Erythropoietin production in hepatocellular carcinoma cells associated with polycythemia: immunohistochemical evidence,” Hepatology, vol. 18, no. 6, pp. 1357–1362, 1993. View at Publisher · View at Google Scholar · View at Scopus
  27. S. C. Tso and A. S. P. Hua, “Erythrocytosis in hepatocellular carcinoma: a compensatory phenomenon,” British Journal of Haematology, vol. 28, no. 4, pp. 497–503, 1974. View at Google Scholar · View at Scopus
  28. R. P. Knill-Jones, R. M. Buckle, V. Parsons, R. Y. Calne, and R. Williams, “Hypercalcemia and increased parathyroid-hormone activity in a primary hepatoma: studies before and after hepatic transplantation,” The New England Journal of Medicine, vol. 282, no. 13, pp. 704–708, 1970. View at Google Scholar · View at Scopus
  29. A. F. Stewart, R. Horst, and L. J. Deftos, “Biochemical evaluation of patients with cancer-associated hypercalcemia. Evidence for humoral and nonhumoral groups,” The New England Journal of Medicine, vol. 303, no. 24, pp. 1377–1383, 1980. View at Google Scholar · View at Scopus
  30. H. W. Seyberth, G. V. Segre, J. L. Morgan et al., “Prostaglandins as mediators of hypercalcemia associated with certain types of cancer,” The New England Journal of Medicine, vol. 293, pp. 1287–1283, 1975. View at Google Scholar
  31. J. W. Wei, H. P. Morris, and R. A. Hickie, “Positive correlation between calmodulin content and hepatoma growth rates,” Cancer Research, vol. 42, pp. 2571–2574, 1982. View at Google Scholar