Differentiation of Human Dermal Mesenchymal Stem Cells into Cardiomyocytes by Treatment with 5-Azacytidine: Concept for Regenerative Therapy in Myocardial Infarction
(a) shows phase-contrast micrographs of untreated control hDMSCs which showed typical MSC-like phenotype. (b) shows long elongated tube-like cells seen on day 14 after hDMSCs were treated with 10 μM of 5-azacytidine for 48 hours. (c) shows day 14 of hDMSCs treated with 20 μM-of 5-azacytidine for 48 hours. These cells showed cardiomyocyte-like cell elongations and cytoplasmic granularity.