Differentiation of Human Dermal Mesenchymal Stem Cells into Cardiomyocytes by Treatment with 5-Azacytidine: Concept for Regenerative Therapy in Myocardial Infarction
(a) shows phase-contrast micrographs of untreated control hDMSCs which showed no change in morphology. (b) shows stick-like appearance on day 4, when hDMSCs were treated with 10 μM of 5-azacytidine for 4 days. These cells became thinner and aligned parallel to each other. (c) shows cardiomyocyte-like appearance of hDMSCs treated with 20 μM-of 5-azacytidine on day 4. These cells are seen in groups of 6-7 cells.