Clinical Study
Computed Tomography Angiography before Intravenous Thrombolysis Does Not Increase the Risk of Renal Dysfunction
Table 3
Patient characteristics according to the presence or absence of acute renal dysfunction.
| | | No acute renal dysfunction | Acute renal dysfunction | P |
| | Age, mean (±SD) | 69.9 (12.9) | 66.1 (10.9) | 0.4 | | Male sex, (%) | 87 (56.9) | 5 (55.6) | 0.9 | | History of diabetes, (%) | 34 (22.2) | 5 (55.6) | 0.02 | | History of hypertension, (%) | 92 (60.1) | 8 (88.9) | 0.08 | | History of chronic renal insufficiency, (%) | 6 (3.9) | 3 (33.3) | <0.001 | | Previous stroke, (%) | 10 (6.5) | 2 (22.2) | 0.08 | | Previous use of metformin, (%) | 25 (16.3) | 3 (33.3) | 0.2 | | Previous use of nonsteroidal anti-inflammatory drugs, (%) | 15 (9.8) | 3 (33.3) | 0.03 | | Baseline NIHSS score, median (IQR) | 14 (8–17.5) | 13 (7–16.5) | 0.4 | | Baseline creatinine >1.5 mg/dL, (%) | 7 (4.6) | 2 (22.2) | 0.02 | | Baseline glucose levels (in mg/dL), mean (±SD) | 131.7 (42.2) | 160.7 (106.2) | 0.08 | | Baseline creatinine levels (in mg/dL), mean (±SD) | 0.94 (0.3) | 1.67 (2.5) | 0.001 | | Creatinine levels within 24–72 hours after IVT (in mg/dL), mean (±SD) | 0.85 (0.31) | 2.16 (2.92) | <0.001 | | Performance of CTA, (%) | 45 (29.4) | 2 (22.2) | 0.6 | | Risk score of CIN (Mehran et al.) [1], mean (only applicable in CTA group) | 5.6 (4.1) | 6.5 (2.1) | 0.7 | | Total contrast dose (mL), mean (±SD) (only applicable in CTA group) | 104.8 (34.1) | 115 (0) | 0.68 |
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SD: standard deviation; NIHSS: National Institutes of Health Stroke Scale; IQR: interquartile range; IVT: intravenous thrombolysis; CTA: computed tomography angiography; CIN: contrast-induced nephropathy.
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