Clinical Study

Computed Tomography Angiography before Intravenous Thrombolysis Does Not Increase the Risk of Renal Dysfunction

Table 4

Univariate and multivariate linear regression analyses to predict creatinine increase in 24–72 hours compared with baseline.

Univariate analysisMultivariate analysis
Standardised coefficientP Standardised coefficientP

Age 0.22
Male sex0.0810.30
History of diabetes 0.0710.37
History of hypertension 0.020.78
History of chronic renal insufficiency 0.41<0.0010.200.01
Previous stroke 0.050.56
Use of metformin 0.64
Baseline glucose levels 0.62
Baseline NIHSS score 0.25
Baseline creatinine0.46<0.0010.30<0.001
Baseline systolic blood pressure 0.78
Use of nonsteroidal anti-inflammatory drugs 0.29<0.0010.190.008
CTA performance 0.31
Risk score of CIN (Mehran et al.) [1] 0.24
Contrast dose 0.19

NIHSS: National Institutes of Health Stroke Scale; CTA: computed tomography angiography; CIN: contrast-induced nephropathy.