Table of Contents
ISRN Organic Chemistry
Volume 2013, Article ID 706437, 13 pages
Research Article

Three Component Reaction: An Efficient Synthesis and Reactions of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Using New Natural Catalyst

Department of Chemistry, Faculty of Science, South Valley University, Qena 83523, Egypt

Received 28 May 2013; Accepted 1 July 2013

Academic Editors: S. Bellemin-Laponnaz, D. K. Chand, T. C. Dinadayalane, and J. Wu

Copyright © 2013 A. M. Elmaghraby et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Synthesis of 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidin-2(1H)-thione derivatives from aldehydes, 1,3-dicarbonyl derivatives and urea or thiourea using granite and quartz as new, natural and reusable catalysts. Some of the 3,4-dihydropyrimidin-2(1H)-thione derivatives were used to prepare new heterocyclic compounds. The antimicrobial activity of selected examples of the synthesized compounds was tested and showed moderate activity.