Three Component Reaction: An Efficient Synthesis and Reactions of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Using New Natural Catalyst

Table 1

3,4-Dihydropyrimidin-2(1H)ones (I).

Entry	R1	R2	Time (h)		MP. [Reference]		Yield^a
			Quartz	Granite	Found	Reported	Quartz	Granite
Ia	C6H5	OEt	3	3.5	201-202	200–202 [33]	68	64
Ib	2-(OH)-C6H4	OEt	3.5	5	202–204	200–202 [34]	62	60
Ic	4-(OCH3)-C6H4	OEt	3	3	199-200	201-202 [35]	64	60
Id	Ph-CH=CH	OEt	3	4	232–234	232–235 [36]	58	55
Ie	2,5-(OCH3)-C6H3	OEt	4	5	210–212	212–214 [37]	61	58
If	3,4,5-(OCH3)-C6H2	OEt	3	4.5	180-181	180–182 [25]	60	56
Ig	2-furyl	OEt	3	4	205-206	203–205 [38]	66	61
Ih	2-(Cl)-C6H4	OEt	3	4	214-215	215-216 [39]	65	62
Ii	4-(OCH3)-C6H4	CH3	3	4	165–167	166–168 [40]	69	65
Ij	4-N(CH3)2-C6H4	OEt	3	4	233–235	230–232 [25]	62	58
Ik	4-(CH3)-C6H4	OEt	2	3	210–212	214-215 [35]	65	62
Il	2,6-(Cl)-C6H3	OEt	4	4.5	302-303	305 [41]	57	61
Im	2-thienyl	OEt	2	3	214–216	215–217 [42]	66	63
In	4-(F)-C6H4	OEt	2	3	175–177	175–177 [43]	71	68
Io	3-(OCH2Ph)-C6H4	OEt	3	3.5	178–180	New	65	62
Ip	3-(OCH2Ph)-C6H4	CH3	3.5	4	192–194	New	40	63
Iq	2,3-(OCH3)-C6H3	OEt	3	4	178–180	New	63	60

aIsolated yield.