Research Article
Three Component Reaction: An Efficient Synthesis and Reactions of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Using New Natural Catalyst
Table 2
3,4-Dihydropyrimidin-2(1H)-thiones (IV).
| Entry | R1 | R2 | R3 | Time (h) | MP. [Reference] | Yielda | Quartz | Granite | Found | Reported | Quartz | Granite |
| IVa | C6H5 | OEt | Ph | 3 | 3 | 183-184 | 183–185 [45] | 63 | 60 | IVb | 4-(OCH3)-C6H4 | CH3 | CH3 | 3.5 | 4 | 181-182 | 183-184 [46] | 67 | 65 | IVc | 2,3-(OCH3)-C6H3 | OEt | CH3 | 3.5 | 4 | 181–183 | New | 64 | 63 | IVd | 4-(OCH3)-C6H4 | OEt | CH3 | 3 | 4 | 152-153 | 150–152 [43] | 59 | 56 | IVe | 2-(OH)-C6H4 | OEt | CH3 | 3 | 4 | 210-211 | 206–208 [47] | 63 | 59 | IVf | 2,6-(Cl)-C6H3 | OEt | CH3 | 4 | 5 | 222–224 | New | 55 | 60 | IVg | 3-(OCH2Ph)-C6H4 | OEt | CH3 | 3 | 4 | 180–182 | New | 66 | 60 | IVh | 2,5-(OCH3)-C6H3 | OEt | CH3 | 4.5 | 5 | 188–190 | New | 64 | 60 |
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Isolated yield.
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