|
Germ layer | Lineage | Author and year | Reference | Induction conditions |
|
Mesoderm | Bone-2D | Zuk et al. 2002 | [21] | Dexamethasone induction |
Leong et al. 2006 | [40] | Vitamin D3 induction |
Behr et al. 2011 | [43] | VEGF supplementation |
Hong et al. 2007 | [44] | 17-estradiol supplementation |
Knippenberg et al. 2007 | [45] | Prostaglandin supplementation |
Park et al. 2011 | [46] | Growth factor-coupled microspheres |
Song et al. 2011 | [47] | BMP2 + vitamin D3 induction |
Chen et al. 2012 | [48] | BMP2 + platelet-rich plasma |
Bone-3D | Hao et al. 2008 | [55] | PLGA scaffolds |
Lee et al. 2008 | [56] |
Marino et al. 2010 | [57] | Tricalcium phosphate scaffolds |
Haimi et al. 2009 | [61] | PLA/Bioactive glass scaffolds |
Leong et al. 2008 | [62] | PCL scaffolds |
Cartilage-2D | Zuk et al. 2002 | [21] | Micromass culture + TGF1 |
Awad et al. 2003 | [84] |
Ogawa et al. 2004 | [66] | Micromass culture + TGF1-GFP+ve mice |
Jin et al. 2007 | [85] | Micromass culture + TGF2-expressing ASCs |
Lu et al. 2012 | [86] | Micromass culture + TGF3-expressing ASCs |
Cartilage-3D | Awad et al. 2004 | [88] | Agarose, alginate and gelatin scaffolds |
Lin et al. 2005 | [89] | Alginate scaffolds |
Yoon et al. 2011 | [91] | Hyaluronate scaffolds |
Adipose | Zuk et al. 2002 | [21] | Dexamethasone, insulin, IBMX, indomethacin |
Ogawa et al. 2004 | [95] | GFP+ve mice |
Rodriguez et al. 2004 | [96] | Serum-free adipogenic medium + rosiglitazone |
Skeletal muscle | Mizuno et al. 2002 | [98] | Reduced serum, hydrocortisone induction |
Lee and Kemp 2006 | [99] | ASC/myoblast co-culture, hypoxic conditions |
Eom et al. 2011 | [100] | Myoblast fusion |
Choi et al. 2012 | [101] | Mechanically patterned hydrogels |
Smooth muscle |
Rodriguez et al. 2006 | [102] | Heparin induction medium |
Wang et al. 2010 |
[103] | TGF1 + BMP4 induction |
Park et al. (In press) | [108] | Elastic nanofibers + stress |
Harris et al. 2011 | [105] | Decellularized vascular grafts |
Wang et al. 2010 | [109] | PGA mesh + pulsatile conditions |
Cardiac muscle |
Planat-Bénard et al. 2004 | [115] | 5-azacytidine induction |
Gaustad et al. 2004 | [114] | Cardiomyocyte cellular extracts |
Choi et al. 2010 | [118] | Cardiomyocyte/ASC co-culture |
Chang et al. 2012 | [119] | PMA treatment |
|
| Neural | Zuk et al. 2002 | [21] | -mercaptoethanol induction |
| Safford et al. 2004 | [121] | Valproic acid, butylated hydroxyanisole, hydrocortisone induction |
| Jang et al. 2010 | [124] | bFGF and forskolin induction |
| Ashjian et al. 2003 | [128] | IBMX, indomethacin, insulin induction |
| Motor neuron | Liqing et al. 2011 | [127] | Retinoic acid + Sonic hedgehog supplementation |
| Schwann cell | Radtke et al. 2009 | [123] | Neurosphere induction |
| Xu et al. 2008 | [131] | Neurosphere induction |
| Kingham et al. 2007 | [130] | Glial growth factor induction (PDGF, bFGF, forskolin) |
| Wei et al. 2010 | [132] | Schwann cell/ASC co-culture |
| Epithelial | Brzoska et al. 2005 | | Retinoic acid treatment |
Ectoderm | Epithelial-vocal fold | Long et al. 2010 | [142] | Air-liquid interface culture |
| Epithelial-urothelium | Liu et al. 2009 | [144] | Epithelial/ASC co-culture |
| Epithelial-retinal | Vossmerbaeumer et al. 2009 | [139] | Retinal pigment epithelial cell-conditioned medium |
| Epidermis | Du et al. 2010 | [134] | Fibrin gel or pellet culture + ascorbate |
| Epidermis | Li et al. 2012 | [135] | Air-liquid interface culture |
| Epidermis/Dermis | Trottier et al. 2008 | [136] | Self-assembly culture system |
| Labbe et al. 2011 | [137] |
| Epithelial-Endothelial | Cao et al. 2005 | [145] | VEGF supplementation |
| Colazzo et al. 2010 | [146] |
| Epithelial-Endothelial | Fisher et al. 2009 | [147] | Shear stress exposure |
| DiMuzio et al. 2007 | [148] |
|
Endoderm | Pancreatic | Timper et al. 2006 | [151] | Pancreatic induction medium |
Chandra et al. 2009 | [152] |
Pancreatic | Lee et al. 2008 | [154] | Pancreatic extract |
Hepatic | Banas et al. 2009 | [159] | Hepatocyte induction medium/CN-coated plates |
Hepatic | Bonora-Centelles 2009 | [160] | HNF4 overexpression |
Lue et al. 2010 | [161] |
Hepatic | Lee et al. 2012 | [162] | Hepatocyte induction medium/CN-coated plates |
|