Clinicopathological Features of Growth Hormone-Producing Pituitary Adenomas in 242 Acromegaly Patients: Classification according to Hormone Production and Cytokeratin Distribution
Figure 1
Immunohistochemical staining of cytokeratin (CK) in adenomas. In predominantly perinuclear (P-pre) perinuclear pattern (PP) adenomas most of the cells have perinuclear CK immunoreactivity. Intermediate (P-inter) PP adenomas contain a mixture of cells with either dot-like or perinuclear patterns of CK. In dot-like pattern (DP) adenomas, dot-like immunoreactivity was detected in more than 80% cells. In negative pattern (NP) adenomas, no significant CK immunoreactivity was detected.
