Table of Contents
ISRN Biomaterials
Volume 2013, Article ID 728791, 14 pages
Review Article

Bioprosthetic Heart Valves: Impact of Implantation on Biomaterials

1Department of Pathology, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, ON, Canada M5G 2C4
2Division of Cardiology, Department of Medicine, University of Toronto, Toronto, ON, Canada
3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

Received 31 December 2012; Accepted 27 January 2013

Academic Editors: J. Foster and D. Letourneur

Copyright © 2013 Pooja Singhal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Prosthetic heart valves are commonly used in the treatment of valvular heart disease. Mechanical valves are more durable than the bioprosthetic valves; however, the need for long-term anticoagulant therapy renders them unsuitable for some patient groups. In this paper we discuss the different types and models of bioprosthesis, and in particular, pericardial bioprosthesis. We also discuss the preimplantation preparation processes, as well as their postimplantation changes and modes of failure.