Table of Contents
ISRN Inflammation
Volume 2013, Article ID 735158, 4 pages
http://dx.doi.org/10.1155/2013/735158
Research Article

Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation

1Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Vidyavihar, Lucknow, Uttar Pradesh 226 025, India
2Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, Allahabad Agricultural Institute-Deemed University, Allahabad, Uttar Pradesh 211 007, India
3Delhi Institute of Pharmaceutical Sciences and Research, (Formerly College of Pharmacy), University of Delhi, Sector III Pushp Vihar, New Delhi, Delhi 110 017, India

Received 18 December 2012; Accepted 10 January 2013

Academic Editors: A. Jalili, B. Kim, and D. Szukiewicz

Copyright © 2013 Gaurav Kaithwas and Dipak K. Majumdar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present investigation summarizes the effect of Linum usitatissimum fixed oil against different phases of acute inflammatory reaction, namely, protein exudation, peritoneal capillary permeability, and leukocyte migration. The fixed oil exhibited dose-dependent inhibition of protein exudation vascular permeability, comparable to standard aspirin. The oil also inhibited the leukocyte migration in pleural exudates in a dose-dependent manner. Production of less vasodilatory (PGE3) and chemotactic (LTB5) eicosanoids through EPA (derived from linolenic acid) metabolism could account for the above observations.