Oxidative Cleavage of β-Lactam Ring of Cephalosporins with Chloramine-T in Alkaline Medium: A Kinetic, Mechanistic, and Reactivity Study

Table 2

Effect of varying dielectric constant (𝐷) of the medium on the rate of reaction at 301 K.

% MeOH (v/v)	𝐷	10^4𝑘^′ ( s^−1)
		CEX	CFL	CPD
0	76.73	2.31	5.15	9.84
10	72.37	1.84	4.76	8.45
20	67.48	1.65	3.98	7.62
30	62.71	1.32	3.28	6.45

Experimental conditions: [CAT]_o = 2.0 × 10⁻⁴ mol dm⁻³; [Substrate]_o = 1.0 × 10⁻³ mol dm⁻³; and [NaOH] = 4.4 × 10⁻³ mol dm⁻³.