Oxidative Cleavage of β-Lactam Ring of Cephalosporins with Chloramine-T in Alkaline Medium: A Kinetic, Mechanistic, and Reactivity Study

Table 4

Effect of varying temperature on the rate of reaction and activation parameters for the oxidation of cephalosporins by CAT in alkaline medium.

Temperature (K)	10^4𝑘^′(s^−1)
	CEX	CFL	CPD
291	1.10	2.82	4.79
296	1.61	4.16	6.46
301	2.31	5.15	9.84
306	3.80	7.90	14.5
𝐸𝑎 (kJ mol^−1)	61.3	53.6	46.7
Δ𝐻^# (kJ mol^−1)	58.8	51.2	44.3
Δ𝐺^# (kJ mol^−1)	94.3	92.2	90.8
Δ𝑆^# (JK^−1 mol^−1)	−119	−137	−156
Log 𝐴	11.3	10.4	9.4

Experimental conditions: [CAT]_o = 2.0 × 10⁻⁴ mol dm⁻³; [Substrate]_o = 1.0 × 10⁻³ mol dm⁻³; and [NaOH] = 4.4 × 10⁻³ mol dm⁻³.