Pulmonary Hypertension Is a Probable NO/ONOO− Cycle Disease: A Review
Table 2
Summary of evidence regarding roles of NO/ONOO− cycle elements in chronic phase of pulmonary arterial hypertension (PAH).
NO/ONOO− cycle element
Elevated?
Response to possible therapeutic agent aimed at lowering?
Other causal evidence?
Oxidative stress
Yes
Yes
Yes
superoxide
Yes
Yes
Yes
ONOO−
Yes
Yes
Yes
NO
?
? only evidence comes from iNOS studies
Yes
NF-B
Yes
Yes
Yes
Inflamm. cytokines
Yes
Yes
Yes
iNOS
Yes
Yes
Yes
Mitochondr. dysfunct
Yes
Yes, limited to PARP studies
Yes
TRP receptors
Yes
Yes
Yes
Intracellular Ca2+
Yes
Yes
Yes
BH4 depletion
Yes
Yes
Yes
NMDA recept activity
?
?
No
The other causal evidence column is limited to either genetic studies or studies, where the element has been reported to have a role in the generation of symptoms and/or signs of PAH.
