International Scholarly Research Notices / 2013 / Article / Tab 1

Clinical Study

Dynamics of B-Cell Populations in CSF and Blood in Patients Treated with a Combination of Rituximab and Mitoxantrone

Table 1

Summary of clinical data of patients under study.

Patient no./sex/age, yrsType of MSTime since initial symptoms, yrsTime since diagnosis, yrsMS therapy in previous 5 yrsEDSS at baselineRelapses in previous 2 yrsMRI findings
(within 6 months before treatment)
T2/T1/T1Gd
OCB

1/F/25RR31None3.0334/22/5+
2/F/21RR32None2.0248/9/3+
3/F/26SP43INFβ-1b 250 μg6.0435/11/3+
4/M/23RR22INFβ-1a 30 μg3.0324/8/2+
5/F/25RR22INFβ-1b 250 μg4.0353/18/3+
6/M/38PP1210GA
Auto-HSCT
6.0438/20/0+
7/F/42RR66Auto-HSCT2.0138/15/5
8/M/28SP1010INFβ-1b 250 μg7.5431/12/10+
9/F/35SP1210Auto-HSCT6.0138/23/0+
10/F/20RR22INFβ-1b 250 μg4.02133/34/7+
11/M/25RR33None4.5423/6/4+
12/F/28RR43INFβ-1b 250 μg Mitoxantrone5.0424/7/8+
13/M/50RR105None4.0140/21/5+
14/M/53RR10GA 6.5224/0/10+
15/F/34RR64GA 4.0130/10/4+
16/F/29RR42None6.0327/8/4+
17/M/29RR1514None6.0492/47/6+
18/F/28RR32INFβ-1b 250 μg4.0233/8/1+
19/M/28SP42None6.0324/8/9+
20/M/30SP33GA mitoxantrone9.0422/13/7+
21/M/51SP1210INFβ-1b 250 μg6.0132/20/0+
22/F/54SP1310GA mitoxantrone6.5328/19/6+
23/M/24RR11None3.03130/40/2+
24/F/44SP65None6.0236/3/1+
25/M/23RRNone4.0212/0/4+
26/F/36RR44None6.034/1/4+
27/F/40RR43None5.5489/23/3+
28/F/55SP33Mitoxantrone8.0422/2/8+

RR: relapsing-remitting; PP: primary progressive; SP: secondary progressive; INFβ: interferon beta; GA: glatiramer acetate; Auto-HSCT: autohematopoietic stem cells transplantation; T2(PD): hyperintense lesions; T1: hypointense lesions; T1Gd: gadolinium-enhanced lesions; OCB: oligoclonal bands.

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