Quantification of Neocortical Slice Diffusion Characteristics Using Pharmacokinetic and Pharmacodynamic Modelling

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="759640.fig.001a" src="https://static.hindawi.com/articles/isrn/volume-2013/759640/figures/759640.fig.001a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>SLE recording</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="759640.fig.001b" src="https://static.hindawi.com/articles/isrn/volume-2013/759640/figures/759640.fig.001b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>SLE frequency </td></tr></table></td></tr><tr class="fig-image" id="c"><td><img alt="759640.fig.001c" src="https://static.hindawi.com/articles/isrn/volume-2013/759640/figures/759640.fig.001c.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(c) </b>Bath concentration-effect loop </td></tr></table></td></tr><tr class="fig-image" id="d"><td><img alt="759640.fig.001d" src="https://static.hindawi.com/articles/isrn/volume-2013/759640/figures/759640.fig.001d.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(d) </b>Tissue concentration-effect loop</td></tr></table></td></tr></table>

<table>Showing the sequence of analysis from (a) raw recording of SLE activity, (b) time-frequency plot of SLE activity, (c) SLE frequency versus bath anesthetic concentration relationship, and (d) collapsed hysteresis loop with fitted inhibitory <svg height="15.4" id="M31" style="vertical-align:-3.3907pt" version="1.1" viewbox="0 0 34.0625 15.4" width="34.0625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> curve, representing the tissue effect-site concentration relationship.</table>

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Figure 1

Figure 1: Quantification of Neocortical Slice Diffusion Characteristics Using Pharmacokinetic and Pharmacodynamic Modelling 