Quantification of Neocortical Slice Diffusion Characteristics Using Pharmacokinetic and Pharmacodynamic Modelling

Table 1

PKPD parameter values: 𝑡_1/2𝐾_𝑒0 (min), 𝐸𝐶₅₀, and gamma. All data are shown as median (range). The 𝐸𝐶₅₀ data is expressed as the proportion of the maximum concentration delivered.

	𝑡1/2𝐾𝑒0	𝐸𝐶50	Gamma
Normal aCSF (𝑛=13)	26.1; (8.6–77.0)	0.113^††; (0.022–0.385)	3.780; (0.81–9.78)
Etomidate (𝑛=14)	83.1*; (19.4–330.1)	0.334; (0.148–0.568)	3.031; (1.34–13.90)
Thiopental (𝑛=14)	111.8*; (27.8–198.0)	0.247^†; (0.017–0.442)	8.912; (0.89–31.57)

^∗𝑃<0.05, compared to normal aCSF, one-way ANOVA, Tukey-Kramer multiple comparisons test.
^††𝑃<0.05, compared to etomidate, one-way ANOVA, Tukey-Kramer multiple comparisons test.
^†𝑃<0.001, compared to etomidate, one-way ANOVA, Tukey-Kramer multiple comparisons test.