Development of a Closed Chest Model of Chronic Myocardial Infarction in Swine: Magnetic Resonance Imaging and Pathological Evaluation

Table 1

Cardiac parameters calculated from magnetic resonance exams performed through the study.

	Baseline	2 hours after induction	Day 7	Day 30		Day 90
				Study group	Control	Study group	Control
Animal weight (kg)	41.33±11.43	41.33±11.43	42.06±11.70	46.80±5.26	43.20±2.77	62.60±8.76	62.20±6.79
EDV (mL)	62.50±10.36	68.21±9.01	74.30±13.08^∗	79.57±19.54^∗	68.46±6.74	99.80±29.70^∗	75.94±8.47
ESV (mL)	28.65±5.15	38.27±7.02^∗	39.62±9.18^∗	45.32±16.66^∗	31.68±6.79	60.69±22.97^∗†	31.91±5.46
EF (%)	53.8±6.32	43.79±7.72^∗	46.54±10.11^∗	44.48±7.76^∗†	54.04±5.81	40.48±6.40^∗†	57.58±8.58
Wall mass (g)	56.67±17.54	64.35±20.62	68.48±18.43	62.46±11.68	57.92±4.42	83.73±17.59	88.68±14.47
CO (L/min)	2.88±0.58	2.63±0.68	2.85±0.79	2.55±0.59	3.32±0.46	2.74±0.79	2.78±0.68
% Infarct MR	n/a	18.09±7.26	12.58±4.10	9.90±5.68	n/a	10.20±4.21	n/a

Data presented as mean ± standard deviation. EDV: end diastolic volume; ESV: end systolic volume; EF: ejection fraction; CO: cardiac output; MR: magnetic resonance; n/a: not applicable. *indicates the existence of statistically significant differences with baseline values (𝑃<0.05). ^†indicates the existence of statistically significant differences with weight matched controls (𝑃<0.05).