|
| Author | Study characteristics | Main results | Complications |
|
| Borgman et al. [25] | Retrospective, 1 field hospital, 246 patients | A plasma to RBC ratio closet to 1 : 1 was associated with improved survival | Increase in MOF and sepsis with a high plasma to RBC ratio |
| Duchesne et al. [26] | Retrospective, 1 level I trauma center in USA, 135 patients | An FFP to RBC ratio close to 1 : 1 was associated with improved survival | Not reported |
| Maegele et al. [27] | Retrospective, multicenter German study, 713 patients | An FFP to RBC ratio close to 1 : 1 was associated with a decrease in mortality rates | Septic complications and MOF increase in the FFP to RBC high ratio group |
| Holcomb et al. [29] | Retrospective, 16 level I trauma centers in USA, 466 patients | The combination of high FFP and high platelets to RBC ratios was associated with increased survival | The combination of high FFP and high platelets to RBC ratios was associated with increased ICU, ventilator and hospital-free days |
| Stinger et al. [30] | Retrospective, 1 field hospital, 252 patients | The transfusion of an increased fibrinogen to RBC ratio was associated with improved survival | Not reported |
| Dente et al. [31] | Prospective, 1 level I trauma center in USA, MT protocol (116 patients) versus historical controls | Increased FFP to RBC and platelets to RBC ratios according to an MT protocol were associated with improved survival in blunt trauma | Not reported |
| Gunter et al. [32] | Retrospective, 1 level I trauma center in USA, 158 patients (MT protocol) | Increased FFP to RBC and platelets to RBC ratios according to an MT protocol were associated with improved survival | Not reported |
| Perkins et al. [33] | Retrospective, 1 field hospital, 694 patients | High platelets (apheresis) to RBC ratios were associated with increased survival | No difference between groups |
| Zink et al. [34] | Retrospective, 16 level I trauma centers in USA, 466 patients | The administration of high ratios of FFP to RBC and platelets to RBC improves survival and decreases overall RBC transfusions | The administration of high platelets to RBC ratios was associated with increased ventilator-free days |
| Shaz et al. [35] | Prospective, 1 level I trauma center in USA, MT protocol versus historical controls, 214 patients | The administration of high ratios of plasma, platelets, and cryoprecipitates to RBC increased survival | Not reported |
| Johansson et al. [36] | Before and after study using historical controls, university hospital in Denmark 832 patients, (MT protocol guided by TEG) | An MT protocol guided by TEG ensuring high FFP and high platelets to RBC ratios was associated with improved survival | Not reported |
| Holcomb et al. [37] | Retrospective, 22 level I trauma centers level 1 in USA, 643 patients | Transfusion of platelet : RBC ratios of 1 : 1 was associated with improved survival | Transfusion of platelet : RBC ratios of 1 : 1 was associated with increased FOM |
| Sperry et al. [38] | Multicenter, prospective USA cohort study, 415 patients (blunt trauma) | An FFP to RBC ratio >1 : 1.5 was associated with a significant lower risk of mortality | A FFP : RBC ratio >1 : 1.5 was associated with a higher risk of ARDS |
| Snyder et al. [39] | Retrospective, 1 level 1 I trauma center in USA, 134 patients | An FFP to RBC ratio close to 1 : 1 was associated with improved survival. However, after adjustment for survival bias, the association was no longer statistically significant | Not reported |
| Kashuk et al. [40] | Retrospective, 1 level I trauma center in USA, 133 patients | The adjusted mortality OR FFP to RBC ratio follows a U-shaped association | Not reported |
| Mitra et al. [41] | Retrospective, 1 level I trauma center in Australia, 331 patients | After excluding deaths in the first 24 hours, the FFP : RBC ratio had no association with mortality | The administration of a high FFP to RBC ratio was associated with increased ventilator and ICU days |
| Teixeira et al. [42] | Retrospective, 1 level 1 I trauma center in USA, 383 patients | The mortality rate decreased with increased FFP transfusion. However, it does not seem to be a survival advantage after a 1 : 3 FFP : PRBC ratio has been reached | Not reported |
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