Evaluation of Analgesic and Anti-Inflammatory Activity of Chloroform and Methanol Extracts of Centella asiatica Linn

Table 2

Effect of Centella asiatica extracts (chloroform and methanol) on acetic acid-induced writhing behavior in mice.

Drugs (dose)	Methanol		Chloroform
	No. of writhing	% Inhibition	No. of writhing	% Inhibition
Control (saline)	49.60±5.12	0.00	49.60±5.12	0.00
Dextropropoxyphene (65 mg/kg)	17.40±2.53^b	64.91	17.40±2.53^b	64.91
Extract (50 mg/kg)	39.00±1.04^a	21.37	22.40±2.67^a	54.28
Extract (100 mg/kg)	37.60±2.07^a	24.19	18.20±2.02^a	62.85
Extract (200 mg/kg)	29.80±0.77^b	39.91	17.70±2.92^b	64.31

Values are mean ± SEM (𝑛=6). Differences in groups were analyzed by one-way analysis of variances (one-way ANOVA) followed by Bonferroni multiple comparison test. ^a𝑃<0.05 and ^b𝑃<0.001 represented highly significant compared to control.