Research Article
Synthesis, Characterization, and BSA Binding Studies of Some New Benzamides Related to Schiff Base
Table 2
Antibacterial and antifungal activity of the synthesized compounds 3 and 5a–j.
| | Compounds | In vitro activity zone of inhibition in mm (MIC in µg/mL)a | | Gram positive | Gram negative | Fungi | | S. aureus | B. subtilis | E. coli | P. aeruginosa | A. niger | A. flavus |
| | 3 | 08 (75) | 07 (75) | 11 (>100) | 10 (>100) | 12.4 (75) | 12.5 (75) | | 5a | 11 (12) | 16 (12) | 12 (25) | 14 (25) | 11 (15) | 10.4 (15) | | 5b | 10 (50) | 10 (30) | 10 (50) | 11 (30) | 12 (25) | 15 (25) | | 5c | 11 (35) | 10 (35) | 15 (50) | 12 (50) | 09 (40) | 15 (40) | | 5d | 12 (30) | 14 (50) | 10 (50) | 13 (50) | 13.7 (25) | 11 (40) | | 5e | 14 (15) | 11 (15) | 09 (25) | 11 (25) | 14.1 (20) | 13.6 (20) | | 5f | 10 (50) | 08 (50) | 11 (100) | 10 (100) | 12 (100) | 10.2 (75) | | 5g | 13.6 (9.8) | 13.5 (10) | 12.7 (12) | 14.0 (10) | 13.2 (10) | 14.0 (15) | | 5h | 14 (12.4) | 12 (12.4) | 11 (25) | 17 (25) | 11.4 (10) | 10.9 (15) | | 5i | 14 (40) | 10 (50) | 11 (30) | 13 (35) | 10 (35) | 14 (30) | | 5j | 12 (35) | 09 (35) | 11 (50) | 13 (50) | 09 (40) | 15 (40) | | Streptomycin | 14.1 (05) | 13.4 (05) | 16.5 (05) | 14 (05) | — | — | | Fluconazole | — | — | — | — | 16 (05) | 19 (05) |
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aAverage of three replicates.
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