Table of Contents
ISRN Nanotechnology
Volume 2013, Article ID 792105, 6 pages
Research Article

Comparative Study on the Synergistic Action of Garlic Synthesized and Citrate Capped Silver Nanoparticles with β-Penem Antibiotics

1Centre for Nanoscience and Nanotechnology, University of Kerala, Thiruvananthapuram, Kerala 695 581, India
2Department of Biotechnology, University of Kerala, Thiruvananthapuram, Kerala 695 581, India

Received 19 June 2013; Accepted 28 July 2013

Academic Editors: L. Baia and Y. Song

Copyright © 2013 Neethu Hari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Resistance to antimicrobial agents by pathogenic bacteria has emerged in recent years and is a major challenge for the health care industry. For developing a cheap broad-active agent that can be applicable against different pathogens, it is necessary to develop an alternative source for normal antibacterial agents. This paper mainly focuses on the combined action of green as well as citrate synthesized silver nanoparticles and β-penem antibiotics, which are β-lactam antibiotics with penem rings. These silver nanoparticles synergistic potential helps in the enhancement of antibacterial activity of broad spectrum antibiotics. The synergistic actions of citrate capped silver nanoparticles (Ag-NPs) were compared with that of garlic (Allium sativum) synthesized silver nanoparticles together with action of antibiotics, ampicillin and amoxyclav, and some of the pathogenic organisms showed an increase in the action of antibiotics.