Nanorod-Shaped Basic Al_𝟐O_𝟑 Catalyzed N,N-Diformylation of Bisuracil Derivatives: A Greener “NOSE” Approach

Table 2

Nano-Al₂O₃ catalyzed N,N-diformylation of uracil and bisuracil derivatives.

Entry	“R” in 1	Product 2	Time (min)	Yield (%)^a,b
1	C6H5(1a)	2a	45	70
2	p-OMeC6H4 (1b)	2b	60	68
3	p-ClC6H4 (1c)	2c	75	58
4	p-OHC6H4 (1d)	2d	90	55
5	p-NO2C6H4 (1e)	2e	90	52
6	p-MeC6H4 (1f)	2f	70	60
7	o-OHC6H4 (1g)	2g	100	52
8	m-NO2C6H4 (1h)	2h	90	65
9	CH3 (1i)	2i	100	52
10	CH3(CH2)3(1j)	2j	120	44
11	2-furyl (1k)	2k	150	57

^a6 mmol of formic acid was used. ^bIsolated yield. ^cProducts were characterized by IR and NMR (¹H and ¹³C) spectroscopy, MS, and also melting points.