Table of Contents
ISRN Analytical Chemistry
Volume 2013, Article ID 795178, 13 pages
Review Article

Pharmaceutical Applications of Chemometric Techniques

1Department of Pharmaceutics, Chitkara College of Pharmacy, Patiala-Chandigarh Highway, Rajpura, Patiala, Punjab 140401, India
2Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa

Received 17 June 2013; Accepted 2 September 2013

Academic Editors: A. M. Haji Shabani, E. Klodzinska, and A. Tsantili-Kakoulidou

Copyright © 2013 Inderbir Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chemometrics involves application of various statistical methods for drawing vital information from various manufacturing-related processes. Multiway chemometric models like parallel factor analysis (PARAFAC), Tucker-3, N-partial least square (N-PLS), and bilinear models like principle component regression (PCR) and partial least squares (PLS) have been discussed in the paper. Chemometric approaches can be used to analyze the data obtained from various instruments including near infrared (NIR), attenuated total reflectance Fourier transform infrared (ATR-FTIR), high-performance liquid chromatography (HPLC), and terahertz pulse spectroscopy. The technique has been used in the quality assurance and quality control of pharmaceutical solid dosage forms. Moreover, application of chemometric methods in the evaluation of properties of pharmaceutical powders and tablet parametric tests has also been discussed in the review. It has been suggested as a useful method for the real-time in-process testing and is a valuable process analytical tool.