Table of Contents
ISRN Pathology
Volume 2013, Article ID 807095, 7 pages
http://dx.doi.org/10.1155/2013/807095
Research Article

Role of HPV-16 in Pathogenesis of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma and Correlation of p16INK4A Expression in HPV-16 Positive Cases: An Immunohistochemical Study

1Department of Oral Pathology and Microbiology, SMBT Dental College and Hospital, Sangamner 422605, India
2Department of Oral Pathology and Microbiology, Vasantdada Patil Dental College and Hospital, Sangli 416416, India
3Department of Oral Pathology and Microbiology, Vananchal Dental College and Hospital, Garhwa, India

Received 15 January 2013; Accepted 14 February 2013

Academic Editors: M. Mokni, A. Sonzogni, and A. Stringer

Copyright © 2013 Gaurav Pralhad Agrawal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Koss, Koss’s Diagnostic Cytology, vol. 1, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 5th edition, 2006.
  2. D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Global cancer statistics, 2002,” CA Cancer Journal for Clinicians, vol. 55, no. 2, pp. 74–108, 2005. View at Google Scholar · View at Scopus
  3. D. Adelstein, J. A. Ridge, M. L. Gillison et al., “Head and neck squamous cell carcinoma & HPV: Summary of national cancer institute state of the science meeting,” Head & Neck, vol. 31, no. 11, pp. 1393–1422, 2009. View at Google Scholar · View at Scopus
  4. R. Rajendran and B. Shivapathasundharam, Eds., Shafers Textbook of Oral Pathology, Elseviers, New York, NY, USA, 6th edition, 2009.
  5. P. Koppikar, E. M. De Villiers, and R. Mulherkar, “Identification of human papillomaviruses in tumors of the oral cavity in an Indian community,” International Journal of Cancer, vol. 113, no. 6, pp. 946–950, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Nair and M. R. Pillai, “Human papillomavirus and disease mechanisms: relevance to oral and cervical cancers,” Oral Diseases, vol. 11, no. 6, pp. 350–359, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Tachezy, J. Klozar, M. Saláková et al., “HPV and other risk factors of oral cavity/oropharyngeal cancer in the Czech Republic,” Oral Diseases, vol. 11, no. 3, pp. 181–185, 2005. View at Google Scholar · View at Scopus
  8. C. Scully, M. F. Cox, S. S. Prime, and N. J. Maitland, “Papillomaviruses: the current status in relation to oral disease,” Oral Surgery Oral Medicine and Oral Pathology, vol. 65, no. 5, pp. 526–532, 1988. View at Google Scholar · View at Scopus
  9. R. O. Greer, K. L. Schroeder, and L. Crosby, “Morphologic and immunohistochemical evidence of human papillomavirus capsid antigen in smokeless tobacco keratoses from juveniles and adults,” Journal of Oral and Maxillofacial Surgery, vol. 46, no. 11, pp. 919–929, 1988. View at Google Scholar · View at Scopus
  10. P. K. Ha and J. A. Califano, “The role of human papillomavirus in oral carcinogenesis,” Critical Reviews in Oral Biology and Medicine, vol. 15, no. 4, pp. 188–196, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Hoffmann, C. Lohrey, A. Hunziker, T. Kahn, and E. Schwarz, “Human papillomavirus type 16 E6 and E7 genotypes in head-and-neck carcinomas,” Oral Oncology, vol. 40, no. 5, pp. 520–524, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Milde-Langosch, S. Riethdorf, A. Kraus-Pöppinghaus, L. Riethdorf, and T. Löning, “Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas,” Virchows Archiv, vol. 439, no. 1, pp. 55–61, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. B. A. Werness, A. J. Levine, and P. M. Howley, “Association of human papillomavirus types 16 and 18 E6 proteins with p53,” Science, vol. 248, no. 4951, pp. 76–79, 1990. View at Google Scholar · View at Scopus
  14. R. Ralham, “Diagnostic potential of genomic and proteomic signatures in oral cancer,” International Journal of Human Genetics, vol. 7, no. 1, pp. 57–66, 2007. View at Google Scholar
  15. A. K. Chaudhary, M. Singh, S. Sundaram, and R. Mehrotra, “Role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review,” Head & Neck Oncology, vol. 1, p. 22, 2009. View at Google Scholar · View at Scopus
  16. C. L. Koo, L. F. Kok, M. Y. Lee et al., “Scoring mechanisms of p16INK4a immunohistochemistry based on either independent nucleic stain or mixed cytoplasmic with nucleic expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study,” Journal of Translational Medicine, vol. 7, p. 25, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. L. L. Cunningham, G. M. Pagano, M. Li et al., “Overexpression of p16INK4a is a reliable marker of human papillomavirus-induced oral high-grade squamous dysplasia,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 102, no. 1, pp. 77–81, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Warnakulasuriya, N. W. Johnson, and I. Van Der Waal, “Nomenclature and classification of potentially malignant disorders of the oral mucosa,” Journal of Oral Pathology and Medicine, vol. 36, no. 10, pp. 575–580, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Barnes, J. W. Eveson, P. Reichart, and D. Sidransky, Eds., WHO Classification of Tumours: Pathology and Genetics of Head and Neck Tumours, ARC Press, Lyon, France, 2005.
  20. H. Mellin, S. Friesland, R. Lewensohn, T. Dalianis, and E. Munck-Wikland, “Human papillomavirus (HPV) DNA in tonsillar cancer: clinical correlates, risk of relapse, and survival,” International Journal of Cancer, vol. 89, no. 3, pp. 300–304, 2000. View at Google Scholar
  21. P. Shah, Text Book of Oral Cancer, Martin Duntitz, London, UK, 2003.
  22. K. Syrjänen, S. Syrjanen, and M. Lamberg, “Morphological and immunohistochemical evidence suggesting human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis,” International Journal of Oral Surgery, vol. 12, no. 6, pp. 418–424, 1983. View at Google Scholar · View at Scopus
  23. S. M. Syrjänen, K. J. Syrjanen, and M. A. Lamberg, “Detection of human papillomavirus DNA in oral mucosal lesions using in situ DNA-hybridization applied on paraffin sections,” Oral Surgery Oral Medicine and Oral Pathology, vol. 62, no. 6, pp. 660–667, 1986. View at Google Scholar · View at Scopus
  24. P. A. G. Fregonesi, D. B. Teresa, R. A. Duarte, C. B. Neto, M. R. B. De Oliveira, and C. P. Soares, “p16INK4a immunohistochemical overexpression in premalignant and malignant oral lesions infected with human papillomavirus,” Journal of Histochemistry and Cytochemistry, vol. 51, no. 10, pp. 1291–1297, 2003. View at Google Scholar · View at Scopus
  25. K. R. Shroyer and R. O. Greer, “Detection of human papillomavirus DNA by in situ DNA hybridization and polymerase chain reaction in premalignant and malignant oral lesions,” Oral Surgery Oral Medicine and Oral Pathology, vol. 71, no. 6, pp. 708–13, 1991. View at Google Scholar · View at Scopus
  26. R. A. Abdelsayed, “Study of human papillomavirus in oral epithelial dysplasia and epidermoid carcinoma in the absence of tobacco and alcohol use,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 71, no. 6, pp. 730–732, 1991. View at Google Scholar · View at Scopus
  27. S. Syrjänen, G. Lodi, I. von Bültzingslöwen et al., “Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review,” Oral Diseases, vol. 17, no. 1, pp. 58–72, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Negri, G. Bellisano, G. F. Zannoni et al., “p16INK4a and HPV L1 immunohistochemistry is helpful for estimating the behavior of low-grade dysplastic lesions of the cervix uteri,” American Journal of Surgical Pathology, vol. 32, no. 11, pp. 1715–1720, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. G. D’Souza, A. R. Kreimer, R. Viscidi et al., “Case-control study of human papillomavirus and oropharyngeal cancer,” The New England Journal of Medicine, vol. 356, pp. 1944–1956, 2007. View at Google Scholar
  30. W. Li, C. H. Thompson, Y. E. Cossart et al., “The expression of key cell cycle markers and presence of human papillomavirus in squamous cell carcinoma of the tonsil,” Head and Neck, vol. 26, no. 1, pp. 1–9, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. N. F. Schlecht, R. D. Burk, L. Adrien et al., “Gene expression profiles in HPV-infected head and neck cancer,” Journal of Pathology, vol. 213, no. 3, pp. 283–293, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. S. K. Young and K. W. Min, “In situ DNA hybridization analysis of oral papillomas, leukoplakias, and carcinomas for human papillomavirus,” Oral Surgery Oral Medicine and Oral Pathology, vol. 71, no. 6, pp. 726–9, 1991. View at Google Scholar · View at Scopus
  33. R. G. McKaig, R. S. Baric, and A. F. Olshan, “Human papillomavirus and head and neck cancer: epidemiology and molecular biology,” Head Neck, vol. 20, no. 3, pp. 250–265, 1998. View at Google Scholar
  34. G. Badaracco, A. Venuti, A. Bartolazzi, R. Morello, F. Marzetti, and M. L. Marcante, “Overexpression of p53 and bcl-2 proteins and the presence of HPV infection are independent events in head and neck cancer,” Journal of Oral Pathology and Medicine, vol. 29, no. 4, pp. 173–179, 2000. View at Publisher · View at Google Scholar · View at Scopus
  35. W. Li, C. H. Thompson, Y. E. Cossart et al., “The expression of key cell cycle markers and presence of human papillomavirus in squamous cell carcinoma of the tonsil,” Head and Neck, vol. 26, no. 1, pp. 1–9, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Tsuchiya, Y. Tomita, H. Shirasawa, H. Tanzawa, K. Sato, and B. Simizu, “Detection of human papillomavirus in head and neck tumors with DNA hybridization and immunohistochemical analysis,” Oral Surgery Oral Medicine and Oral Pathology, vol. 71, no. 6, pp. 721–5, 1991. View at Google Scholar · View at Scopus
  37. K. Kurose, M. Terai, N. Soedarsono et al., “Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 98, no. 1, pp. 91–96, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. I. B. F. Cruz, P. J. F. Snijders, R. D. M. Steenbergen et al., “Age-dependence of human papillomavirus DNA presence in oral squamous cell carcinomas,” European Journal of Cancer B, vol. 32, no. 1, pp. 55–62, 1996. View at Publisher · View at Google Scholar · View at Scopus
  39. H. Jalal, C. M. Sanders, S. S. Prime, C. Scully, and N. J. Maitland, “Detection of human pappiloma virus type 16 DNA in oral squames from normal young adults,” Journal of Oral Pathology and Medicine, vol. 21, no. 10, pp. 465–470, 1992. View at Publisher · View at Google Scholar · View at Scopus
  40. B. Samama, D. Lipsker, and N. Boehm, “p16 expression in relation to human papillomavirus in anogenital lesions,” Human Pathology, vol. 37, no. 5, pp. 513–519, 2006. View at Publisher · View at Google Scholar · View at Scopus