Current Understanding of Guanylin Peptides Actions

Table 2

Expression of cytoplasmic and membrane-bound guanylate cyclases.

Cyclases	Tissue distribution	Agonists
Cytoplasmic	Skeletal muscle, platelets, lung, liver, kidney, heart, and CNS	NO, CO
GC-A	Smooth muscle, kidney, adrenal gland, heart, and CNS	ANP, BNP
GC-B	Fibroblasts, heart, and CNS	CNP
GC-C	Intestine, adrenal gland, CNS, lung, reproductive glands, and kidney	STa, GN, and UGN
GC-D	Olfactory cells	GN, UGN
GC-E	Retina	Unknown
GC-F	Retina	Unknown
GC-G	Skeletal muscle, lung, intestine, and kidney	Unknown

ANP: atrial natriuretic peptide, BNP: brain natriuretic peptide, CNP: C-type natriuretic peptide, CNS: central nervous system, CO: carbon monoxide, NO: nitric oxide, STa: heat-stable enterotoxin of Escherichia coli, GN: guanylin, and UGN: uroguanylin.