Effects of Rituximab on the Development of Viral and Fungal Infections in Renal Transplant Recipients

Table 2

Baseline and posttransplant immunosuppression.

Variable	RTX; 𝑛=55	No RTX; 𝑛=386	𝑃 value
IL2ra induction, % (𝑛)	18 (10)	40 (156)	<0.001
Perioperative ATG, % (𝑛)	84 (46)	63 (242)	0.001
Perioperative IVIG, % (𝑛)	33 (18)	2 (5)	<0.001
Tacrolimus at discharge, % (𝑛)	100 (55)	100 (386)
Mycophenolate at discharge, % (𝑛)	100 (55)	100 (386)
Prednisone withdrawal, % (𝑛)	5 (3)	13 (51)	0.07
Acute rejection, % (𝑛)	51 (28)	15 (56)	<0.001
Antibody-mediated rejection, % (𝑛)	23 (12)	3 (11)	<0.001
ATG for rejection, % (𝑛)	29 (16)	7 (28)	<0.001
Total ATG exposure, (mg/kg)	8.5±6.5	5.7±2.4	<0.001

Abbreviations—IL2ra: interleukin-2 receptor antagonist; ATG: antithymocyte globulin; IVIG: intravenous immune globulin.
^aConcurrent viral disease includes history of hepatitis B, hepatitis C, or human Immunodeficiency virus.