Table 1: Modulation of the immune response by HHV-6A and HHV-6B in different cell types.

Cell typeHHV-6AHHV-6BReferences

Lymphoid cells
 PBMC IL-1β b, TNFα b, IFNα b, IL-10, IL-15
IL-12, IFNγ, IL-2
[29, 4143]
 T cells (primary and cell lines) IL-18, IL-2R, IFNγR, CCL-2
IL-10, IL-14, IL-10R, IL-13R, IL-2
IL-18, IL-2R
IL-10, IL-14, IL-10R, IL-13R
[29, 44, 45]
 NK cells IL-15, cytotoxicity[46]
 Monocytes (primary and cell lines) TNFα, IL-10, IL-12, IL-15[47, 48, 126]
 Tonsillar cells (ex vivo) CCL-5 CCL-5[50, 51]
 Dendritic cells maturationb, IL-12b IFNλ-1b
maturationb, IL-12b
[40, 49]
 Macrophages IL-12[39]
Brain cells
 Astrocytes (primary and cell line) CCL-5, CCL-2, IL-6, CXCL-2, CCL-3, IL-1β, GM-CSF, CXCL-6, IL-10, TNFα, IL-7R
IL-6b, IL-1β b[45, 127]
Other cell types
 Endothelial cells CCL-5, CXCL-8, CCL-2[52, 53]
 Hepatoma cells CXCL-8a[54]

: enhanced production; : inhibited production.
aReplication-dependent effect; breplication-independent effect.