Table of Contents
ISRN Gastroenterology
Volume 2013, Article ID 840690, 8 pages
Review Article

Differences in the Characteristics of Barrett’s Esophagus and Barrett’s Adenocarcinoma between the United States and Japan

Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu, Kagawa 761-0793, Japan

Received 8 February 2013; Accepted 10 March 2013

Academic Editors: P. Correa, A. Giacosa, V. Savarino, and C. Y. Yeung

Copyright © 2013 Makoto Oryu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In Europe and the United States, the incidence of esophageal adenocarcinoma has increased 6-fold in the last 25 years and currently accounts for more than 50% of all esophageal cancers. Barrett’s esophagus is the source of Barrett’s adenocarcinoma and is characterized by the replacement of squamous epithelium with columnar epithelium in the lower esophagus due to chronic gastroesophageal reflux disease (GERD). Even though the prevalence of GERD has recently been increasing in Japan as well as in Europe and the United States, the clinical situation of Barrett’s esophagus and Barrett’s adenocarcinoma differs from that in Western countries. In this paper, we focus on specific differences in the background factors and pathophysiology of these lesions.