Development of Dengue Infection Severity Score

Table 1

Patient profiles by types of dengue infection: dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS).

Patient profiles	DF (𝑛=391)	DHF (𝑛=296)	DSS (𝑛=90)	𝑃 value*
	Mean ± SD	Mean ± SD	Mean ± SD
Demographic
Male (𝑛, %)	185 (47.3)	153 (51.7)	38 (42.2)	0.888
Age (year)	9.5±3.4	10.1±3.1	9.0±3.5	0.903
Mode of presentation
Hepatomegaly (𝑛, %)	8 (2.1)	26 (8.8)	55 (61.1)	<0.001
Headache (𝑛, %)	228 (58.3)	145 (49.0)	35 (38.9)	<0.001
Myalgia (𝑛, %)	84 (21.5)	30 (10.1)	12 (13.3)	0.001
Vomiting (𝑛, %)	244 (62.4)	216 (73.0)	56 (62.2)	0.187
Cough (𝑛, %)	120 (30.7)	94 (31.8)	32 (35.6)	0.425
Abdominal pain (𝑛, %)	160 (40.9)	181 (61.2)	60 (66.7)	<0.001
Rash (𝑛, %)	166 (42.5)	132 (44.6)	26 (28.9)	0.124
Pleural effusion (𝑛, %)	0 (0)	20 (6.8)	34 (37.8)	<0.001
Petechiae (𝑛, %)	27 (6.9)	26 (8.8)	14 (15.6)	0.016
Any bleeding episodes (𝑛, %)	73 (18.7)	80 (27.0)	51 (56.7)	<0.001
Hemodynamic
SBP (mmHg)	97.0±9.2	96.9±10.1	91.3±10.3	<0.001
DBP (mmHg)	58.4±7.7	58.2±8.6	58.6±8.4	0.084
Pulse pressure (mmHg)	33.1±6.7	32.1±7.6	24.0±7.7	<0.001
Hematological
Hematocrit (%)	38.8±4.5	40.5±4.8	42.4±5.4	<0.001
Hemoglobin (g/dL)	12.7±1.5	13.4±1.5	14.1±1.8	<0.001
White cell count (/µL)	3748.0±1706.5	4271.3±1821.8	5479.3±2063.4	<0.001
Lymphocytes (%)	44.9±17.3	40.8±15.7	40.0±16.3	<0.001
Neutrophils (%)	44.7±18.8	49.5±18.1	48.9±17.6	<0.001
Platelet (/µL)	122693.6±9763.9	81869.0±7975.7	50481.5±6262.9	<0.001
Biochemical
AST (U/L)	126.7±313.7	269.0±457.1	558.9±659.0	<0.001
ALT (U/L)	60.1±216.1	95.0±271.7	219.8±413.2	0.001
PT (sec)	12.0±1.5	12.1±1.8	15.5±9.5	0.012
PTT (sec)	30.4±5.4	42.0±10.0	44.7±12.3	0.004
Case management
Inbound referral (𝑛, %)	43 (11.0)	78 (26.4)	48 (53.3)	<0.001
Discharged
Alive (𝑛, %)	391 (100.0)	296 (100.0)	88 (97.8)	1.000
Outbound referral (𝑛, %)	0 (0)	0 (0)	2 (2.2)
In hospital dead (𝑛, %)	0 (0)	0 (0)	0 (0)

 ^∗𝑃 value from nonparametric test for trend.
SD: standard deviation; SBP: systolic blood pressure; DBP: diastolic blood pressure; AST: aspartate aminotransferase; ALT: alanine aminotransferase; PT: prothrombin time; PTT: partial thromboplastin time.