The Epidermal Growth Factor Receptor Increases Cytokine Production and Cutaneous Inflammation in Response to Ultraviolet Irradiation
Figure 4
EGFR increases COX-2 levels in keratinocytes following UV exposure. (a) Subconfluent keratinocytes were treated with 1 μM AG1478 or vehicle 2 h prior to 200 J/m2 UV irradiation or sham-irradiation. (b) Subconfluent Egfr-null and wild-type keratinocytes were UV-exposed (200 J/m2) or sham-irradiated. (a)-(b) Sixteen hours after irradiation, protein lysate was prepared. Samples were immunoblotted with the indicated antibodies. Data are representative of three experiments performed with similar results.
