Table of Contents
ISRN Pediatrics
Volume 2013, Article ID 849709, 5 pages
Research Article

Role of Organochlorine Pesticides in Children with Idiopathic Seizures

1Department of Pediatrics, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi 110095, India
2Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Dilshad Garden, Delhi-95, India
3Department of Biochemistry, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi 110095, India

Received 27 August 2013; Accepted 7 October 2013

Academic Editors: C. Casey and D. D. Trevisanuto

Copyright © 2013 Shilpa Khanna Arora et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Organochlorine pesticides (OCP) are persistent organic pollutants that have been implicated in causing several deleterious effects in humans. These are known neurotoxins in high doses, but the role of environmentally acquired OCPs in the body to induce seizures in children has not been investigated yet. Objectives. To assess the serum levels of OCPs in children aged 2–12 with idiopathic seizure and to find out any association between the two are our objectives. Methods. It was a cross-sectional pilot study. Twenty developmentally normal children aged 2–12, presenting with idiopathic generalized seizures, were recruited. Twenty age-matched controls without any history of seizures were also taken. Their serum levels of , , and hexachlorocyclohexane (HCH); and aldrin; dieldrin; p,p-dichlorodiphenyltrichloroethane (DDT), o,p-DDT, and p,p dichlorodiphenyldichloroethylene (DDE); and and endosulfan were analysed using gas chromatography (GC). Mann-Whitney test was used to compare OCP levels between the groups. Spearman correlation was used to find the correlation between individual pesticide levels with age and seizure duration. Results. Levels of , , and total HCH were significantly higher among cases as compared to the control group ( ). Conclusion. There exists a possible association between idiopathic seizures and high serum levels of OCPs, especially HCH.