Review Article
A Practical Update of Surgical Management of Merkel Cell Carcinoma of the Skin
Table 5
Important prognostic factors for disease-free survival [
8].
| Favorable | | Initial localized disease | | Surgery as part of the treatment | | Adjuvant radiotherapy | | Unfavorable | | Age > 70 years | | Male sex | | Trunk site | | Head and neck site—especially lip | | Size of primary > 2 cm | | Initial nodal disease presentation, especially if >2 Involved nodes | | Initial distant disease presentation | | Histology—small-cell size, high mitotic rate, depth of invasion | | Lymphovascular invasion | | Infiltrative, rather than a nodular, growth pattern | |
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