Possible Mechanisms by Which Topical 5-Fluorouracil and Dermabrasion Could Induce Pigment Spread in Vitiligo Skin: An Experimental Study

Table 1

Consequences of different treatments on epithelialization and inflammatory.

Treatment	Time for healing	Inflammatory reaction duration	Pigment spread; distance
Topical 5-FU ointment; 𝑛=2	—	—	0
Dermabrasion alone; 𝑛=2	7 days	8 days	Few mms
Dermabrasion + 5-FU; 𝑛=3	15 to 17 days	20 to 27 days	1.5 to 2.5 cms; 2 ± 0.5 cm

Reaction and pigment spread. 𝑛: number of treated guinea pigs.