Review Article
A Clinical Review of the Association of Thyroid Stimulating Hormone and Cognitive Impairment
Table 1
Longitudinal population-based studies. Relationship between subclinical hyperthyroidism (SH) and cognitive decline.
| | Author | Study size () | Mean age | Followup
(years) | Participants
thyroid status | Thyroid function
(normal range) | Outcomes |
| |
Vadiveloo et al., 2011 [25]
| 12.115 | | 5.6 (median) | SH and euthyroid | TSH (0.4–4.0 mU/L)
FT4 (10–25 pmol/L)
FT3 (0.9–2.6 nmol/L) | Positive association
SH and dementia |
| | de Jong et al., 2009 [26] | 615 | 77.5 | 5 | SH and euthyroid | TSH (0.4–4.3 mU/L)
FT4 (0.85–1.94 ng/L) | Positive association
FT4 and dementia/AD |
| | Tan et al., 2008 [27] | 1.864 | 71 | 12.7 | SH and euthyroid | TSH (0.5–5.0 mU/L) | Positive association
Lowest and highest tertile
TSH and AD |
| | Yeap et al., 2012 [28] | 3401 | 76.8 | 5.9 | Euthyroid only | TSH (0.4–4.3 mU/L)
FT4 (10–23 pmol/L) | Positive association
FT4 and dementia |
| | Forti et al., 2012 [29] | 660 | | 3.8 ± 0.7 | Euthyroid and
subclinical hypothyroidism | TSH (0.45–4.5 mU/L)
FT4 (10.3–25.7 pmol/L) | No association
TSH and MCI/AD
Positive association High TSH and VAD |
| | S. Annerbo et al., 2009 [30] | 200 | | 6.7 | All thyroid status
(mean TSH 1.76 ± 1.03) | TSH (0.2–4.0 mU/L) TT4 | No association
TSH and AD |
|
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